Patient P-01547

Synthetic patientNBL-101 · Day 109 · 55–64 · F · baseline S13Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Stable

GI state

Stable

Inflammatory state

Improving

Nutritional resilience

Stable

Discontinuation risk

56%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S13
Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 60 GI-04 recommended — GI Support Protocol GI-04
Day 61 Patient accepted — Started GI-04 in the companion
Day 62 ME-01 recommended — Monitoring Escalation ME-01
Day 63 Patient accepted — Started ME-01 in the companion
Day 66 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
Day 69 GI symptom burden −25% vs expected — GI Support Protocol GI-04
Day 75 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 49.

Primary contributors, last 14 days

Treatment adherence+7
Inflammatory activity-4
Nutritional resilience-2

What helped?

GI Support Protocol GI-04Day 60
Result: symptom burden −25%
Monitoring Escalation ME-01Day 62
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

51%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

48.4/100

stable · -0.3 vs previous 14 d

Toxicity

Blood

52/100

improving · -4.8 vs previous 14 d

Sleep quality

Wearable

41.1/100

stable · -0.9 vs previous 14 d

Energy level

Daily log

3.1/10

stable · +0.0 vs previous 14 d

Stress level

Daily log

6.3/10

stable · -0.2 vs previous 14 d

Steps

Wearable

6,195

improving · +358 vs previous 14 d

Adherence

Companion

50.4 %

stable · -1.5 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 39 from the failing basin, 49 from restoration.

Good elements to keep

GI Support Protocol GI-04
intervention · steering +37.6
Monitoring Escalation ME-01
intervention · steering +4.6
Daily walks resumed
perturbation · steering +3.3

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
FUT2 non-secretor
hidden · steering -10.6
Dietary fat load
perturbation · steering -10.1
Insoluble fibre
perturbation · steering -9
Dietary fat load
detractor · GI +5.3 next day
Insoluble fibre
detractor · GI +4.8 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+5.3detractor · 95%
Insoluble fibre
+4.8detractor · 95%
Histamine load
+4.5detractor · 95%
Spicy / capsaicin
+3.6detractor · 95%
Simple carbohydrates
+3.4detractor · 90%
Alcohol
+2.8detractor · 94%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 48 and rising
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 27/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 47
Drug metabolism and exposure ↑20
- BloodToxicity index 52

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.1 · butyrate capacity 27/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 47 ms
Sleep: 6.4 h
Steps: 6,231
Resting HR: 70 bpm

Daily log: GI score 48, nutritional resilience 42, adherence 50.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	22%	S11	AD-05	no change	42
P-01708	34%	S07	CR-01	improved	59
P-01371	31%	S06	CR-01	improved	63
P-01696	31%	S20	CR-01	improved	59
P-01442	30%	S13	CR-01	improved	61
P-01835	29%	S17	CR-01	improved	56
P-01388	28%	S17	CR-01	improved	59
P-01877	27%	S01	CR-01	improved	67
P-01430	23%	S05	CR-01	improved	54
P-01342	22%	S11	DT-01	improved	48
P-01433	53%	S14	GI-04	improved	48
P-01494	51%	S14	GI-04	improved	42