Patient P-01572

Synthetic patientNBL-101 · Day 117 · 55–64 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

87%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 46 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 51 SC-12 recommended — Supportive Compound SC-12
Day 52 Patient declined — Not now
Day 54 GI-04 recommended — GI Support Protocol GI-04
Day 55 Patient accepted — Started GI-04 in the companion
Day 63 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 46.

Primary contributors, last 14 days

Treatment adherence-9
GI instability-6
Toxicity+6
Nutritional resilience+4
Inflammatory activity+3

What helped?

Supportive Compound SC-12Day 51
Declined by patient
GI Support Protocol GI-04Day 54
Result: no meaningful change

LIFE OS recommendation

Dietary Support Protocol NP-02

57%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

75.8/100

stable · -1.4 vs previous 14 d

Toxicity

Blood

55.7/100

worsening · +4.6 vs previous 14 d

Sleep quality

Wearable

22.6/100

worsening · -1.5 vs previous 14 d

Energy level

Daily log

0.6/10

stable · -0.0 vs previous 14 d

Stress level

Daily log

7.7/10

stable · +0.0 vs previous 14 d

Steps

Wearable

4,412

worsening · -387 vs previous 14 d

Adherence

Companion

38.5 %

worsening · -3.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 19 from the failing basin, 84 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 69%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 69%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 69%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep fibre low
GI +3 next day on high-intake days · n 19
Keep simple carbs low
GI +2.3 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Insoluble fibre
+3detractor · 95%
Simple carbohydrates
+2.3detractor · 63%
Histamine load
+1.6no signal · 48%
Dietary fat load
+1.4no signal · 37%
Alcohol
+0.5no signal · 15%
Spicy / capsaicin
-0.4no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 71
Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 76 and rising
- WearableSleep 5.2 h, below personal baseline
Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑45
- WearableResting HR 75 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 56

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.1 · butyrate capacity 46/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 48 ms
Sleep: 5.2 h
Steps: 2,888
Resting HR: 77 bpm

Daily log: GI score 76, nutritional resilience 32, adherence 39.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01897	61%	S14	ME-01	improved	43
P-01612	53%	S14	ME-01	improved	51
P-01728	53%	S14	SC-12	improved	41
P-01736	53%	S03	ME-01	improved	46
P-01531	49%	S14	ME-01	improved	51
P-01615	48%	S14	ME-01	improved	48
P-01656	47%	S14	ME-01	improved	41
P-01564	46%	S14	ME-01	improved	39
P-01605	46%	S14	ME-01	improved	41
P-01751	45%	S14	ME-01	improved	48
P-01412	44%	S14	NP-02	improved	49
P-01801	44%	S14	SC-12	improved	42