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Patient P-01592

Synthetic patientNBL-101 · Day 116 · 35–44 · F · baseline S04Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
50%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S04

What changed?

Trajectory is tracking the baseline prediction.

Primary contributors, last 14 days
  • GI instability+17
  • Nutritional resilience-14
  • Inflammatory activity+13
  • Toxicity+6
  • Treatment adherence+2

What helped?

No interventions yet.

    LIFE OS recommendation
    GI Support Protocol GI-04
    63%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 91% showed improvement
    • median effect visible after 8 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    43.4/100
    worsening · +4.0 vs previous 14 d
    Toxicity
    Blood
    26.7/100
    worsening · +3.8 vs previous 14 d
    Sleep quality
    Wearable
    33/100
    improving · +3.1 vs previous 14 d
    Energy level
    Daily log
    4.9/10
    stable · -0.0 vs previous 14 d
    Stress level
    Daily log
    5.9/10
    stable · +0.1 vs previous 14 d
    Steps
    Wearable
    2,006
    worsening · -420 vs previous 14 d
    Adherence
    Companion
    93.8 %
    stable · -0.5 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards failing · 48 from the failing basin, 40 from restoration.

    Would help
    • GI-04 GI Support Protocol
      89% improved among 63 similar · onset 8 d · confidence 56%
    • NP-02 Dietary Support Protocol
      67% improved among 27 similar · onset 10 d · confidence 64%
    • DT-01 Dosing / Timing Recommendation
      67% improved among 6 similar · onset 5 d · confidence 64%
    Would not help
    • HY-01 Hydration Protocol
      only 40% improved among 10 similar
    • Keep alcohol low
      GI +3.7 next day on high-intake days · n 21
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Alcohol
      +3.7detractor · 95%
    • Insoluble fibre
      +1.6no signal · 30%
    • Spicy / capsaicin
      -1.3no signal · 28%
    • Simple carbohydrates
      -0.9no signal · 19%
    • Dietary fat load
      +0.3no signal · 15%
    • Histamine load
      -0.1no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Drug metabolism and exposure ↑75
      • DNACYP2D6 poor metabolizer → higher exposure
      • DNADPYD *2A → slower clearance
    • Autonomic recovery ↓45
      • WearableResting HR 79 bpm
      • Wearable2,006 steps/day
    • Inflammatory signalling ↑40
      • BloodInflammatory load index 40
      • WearableHRV 21 ms, trending down
    • Mucosal barrier integrity ↓30
      • MicrobiomeAkkermansia low → thinner mucus layer
    • Butyrate / short-chain fatty acid production ↓20
      • Daily logFibre intake low in recent food logs
    DNA
    Fictional pharmacogenomic panel
    • DPYD *2A heterozygous
      Slower drug clearance
    • CYP2D6 Poor metabolizer
      Higher exposure at standard dose
    • MTHFR C677T
      Reduced folate turnover
    Microbiome
    Shannon diversity 4.4 · butyrate capacity 75/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisNormal
    • Bifidobacterium longumNormal
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    25 ms
    Sleep
    6.2 h
    Steps
    2,606
    Resting HR
    78 bpm
    Daily log: GI score 43, nutritional resilience 48, adherence 94.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
    • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Track each bowel movement today: time, stool form, urgency, overnight waking
    • A 15-minute walk after lunch
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • Electrolyte solution, one sachet after any loose stool
    • Fictional demo item: oral nutrition supplement with lunch

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
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    P-0182337%S01——57
    P-0160436%S01——71
    P-0182136%S01——58
    P-0170329%S01——51
    P-0184629%S01——37
    P-0168828%S01GI-04improved40
    P-0131027%S01——57
    P-0145527%S01GI-04improved61
    P-0181627%S01——35
    P-0131326%S01BR-03improved32
    P-0132726%S01GI-04improved56
    P-0149940%S02——65