Patient P-01612
Synthetic patientNBL-101 · Day 112 · 25–34 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 52 GI-04 recommended — GI Support Protocol GI-04
- Day 53 Patient declined — Not now
- Day 68 ME-01 recommended — Monitoring Escalation ME-01
- Day 69 Patient accepted — Started ME-01 in the companion
- Day 72 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- Toxicity+15
- Nutritional resilience-7
- GI instability-4
What helped?
- GI Support Protocol GI-04Day 52Declined by patient
- Monitoring Escalation ME-01Day 68Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion64.9/100
stable · -1.5 vs previous 14 d
Toxicity
Blood61.7/100
stable · -1.9 vs previous 14 d
Sleep quality
Wearable37.8/100
worsening · -2.8 vs previous 14 d
Energy level
Daily log2.5/10
improving · +0.1 vs previous 14 d
Stress level
Daily log6.3/10
stable · -0.1 vs previous 14 d
Steps
Wearable3,953
stable · +88 vs previous 14 d
Adherence
Companion44.5 %
stable · +0.6 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 27 from the failing basin, 69 from restoration.
Would help
Would not help
- Keep fat lowGI +5.7 next day on high-intake days · n 22
- Keep histamine lowGI +5.6 next day on high-intake days · n 17
- Keep fibre lowGI +4.7 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+5.7detractor · 95%
- Histamine load+5.6detractor · 95%
- Insoluble fibre+4.7detractor · 95%
- Simple carbohydrates+3.9detractor · 92%
- Spicy / capsaicin+1.1no signal · 20%
- Alcohol+0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 65 and rising
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 23/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 64
- Autonomic recovery ↓45
- WearableResting HR 88 bpm
- Wearable3,953 steps/day
- Drug metabolism and exposure ↑20
- BloodToxicity index 62
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.4 · butyrate capacity 23/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 52 ms
- Sleep
- 6.4 h
- Steps
- 4,708
- Resting HR
- 87 bpm
Daily log: GI score 65, nutritional resilience 32, adherence 45.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01841 | 64% | S14 | — | — | 48 |
| P-01582 | 57% | S14 | GI-04 | no change | 45 |
| P-01888 | 55% | S14 | — | — | 56 |
| P-01463 | 54% | S14 | NP-02 | no change | 41 |
| P-01531 | 54% | S14 | ME-01 | improved | 51 |
| P-01728 | 54% | S14 | SC-12 | improved | 41 |
| P-01572 | 53% | S14 | GI-04 | worsened | 41 |
| P-01743 | 53% | S14 | SC-12 | no change | 52 |
| P-01396 | 52% | S14 | GI-04 | worsened | 51 |
| P-01751 | 52% | S14 | ME-01 | improved | 48 |
| P-01830 | 52% | S14 | — | — | 44 |
| P-01897 | 52% | S14 | ME-01 | improved | 43 |