Patient P-01623
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Improving
Nutritional resilience
Unstable
Discontinuation risk
56%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S16
- Day 82 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 82.
Primary contributors, last 14 days
- Treatment adherence-12
- Inflammatory activity-9
- Toxicity-8
- Nutritional resilience-5
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
58%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion60.6/100
worsening · +9.1 vs previous 14 d
Toxicity
Blood49/100
worsening · +6.2 vs previous 14 d
Sleep quality
Wearable23.9/100
worsening · -1.8 vs previous 14 d
Energy level
Daily log2.9/10
worsening · -0.9 vs previous 14 d
Stress level
Daily log8.1/10
worsening · +0.7 vs previous 14 d
Steps
Wearable7,697
stable · -110 vs previous 14 d
Adherence
Companion67 %
worsening · -17.0 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →Heading towards restoration · 33 from the failing basin, 59 from restoration.
Good elements to keep
- Daily walks resumedperturbation · steering +3.3
Main detractors to watch
- Low butyrate capacityhidden · steering -17.5
- FUT2 non-secretorhidden · steering -10.6
- Dietary fat loadperturbation · steering -9.2
- Low microbial diversityhidden · steering -7.7
- Dietary fat loaddetractor · GI +4.9 next day
- Histamine loaddetractor · GI +3.5 next day
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+4.9detractor · 95%
- Histamine load+3.5detractor · 95%
- Simple carbohydrates+2.1detractor · 74%
- Alcohol+2no signal · 54%
- Insoluble fibre+1.4no signal · 40%
- Spicy / capsaicin+0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 54
- WearableHRV 21 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 49
- Autonomic recovery ↑20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.1 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 19 ms
- Sleep
- 6.0 h
- Steps
- 7,444
- Resting HR
- 71 bpm
Daily log: GI score 61, nutritional resilience 36, adherence 67.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01835 | 51% | S17 | CR-01 | improved | 56 |
| P-01388 | 46% | S17 | CR-01 | improved | 59 |
| P-01696 | 44% | S20 | CR-01 | improved | 59 |
| P-01877 | 43% | S01 | CR-01 | improved | 67 |
| P-01699 | 40% | S04 | GI-04 | improved | 69 |
| P-01371 | 39% | S06 | CR-01 | improved | 63 |
| P-01708 | 39% | S07 | CR-01 | improved | 59 |
| P-01442 | 38% | S13 | CR-01 | improved | 61 |
| P-01349 | 37% | S14 | GI-04 | improved | 38 |
| P-01336 | 36% | S03 | GI-04 | improved | 51 |
| P-01393 | 36% | S14 | GI-04 | improved | 53 |
| P-01433 | 36% | S14 | GI-04 | improved | 48 |