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Patient P-01629

Synthetic patientNBL-101 · Day 118 · 65–74 · M · baseline S19Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Stable
Discontinuation risk
28%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S19
  2. Day 88 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 88.

Primary contributors, last 14 days
  • GI instability+5
  • Inflammatory activity+5
  • Nutritional resilience-2
  • Treatment adherence+2

What helped?

No interventions yet.

    LIFE OS recommendation
    No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    37.7/100
    improving · -3.8 vs previous 14 d
    Toxicity
    Blood
    17.1/100
    improving · -1.1 vs previous 14 d
    Sleep quality
    Wearable
    36/100
    improving · +5.0 vs previous 14 d
    Energy level
    Daily log
    5.4/10
    improving · +0.5 vs previous 14 d
    Stress level
    Daily log
    5/10
    improving · -0.4 vs previous 14 d
    Steps
    Wearable
    6,994
    improving · +511 vs previous 14 d
    Adherence
    Companion
    94.9 %
    worsening · -5.1 vs previous 14 d
    This trajectory is doing well — what to keep, what to watch
    Steering view →

    Heading towards restoration · 61 from the failing basin, 27 from restoration.

    Good elements to keep
    • Butyrate producers intact
      hidden · steering +7.5
    • Daily walks resumed
      perturbation · steering +3.3
    Main detractors to watch
    • Poor metabolizer
      hidden · steering -12.7
    • FUT2 non-secretor
      hidden · steering -10.6
    • Histamine load
      perturbation · steering -8.2
    • Enterobacteriaceae elevated
      hidden · steering -7.4
    • Histamine load
      detractor · GI +4.8 next day
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +4.8detractor · 95%
    • Simple carbohydrates
      -1.2no signal · 28%
    • Insoluble fibre
      -1no signal · 22%
    • Dietary fat load
      +0.9no signal · 15%
    • Spicy / capsaicin
      -0.7no signal · 15%
    • Alcohol
      -0.5no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Drug metabolism and exposure ↑40
      • DNACYP2D6 poor metabolizer → higher exposure
    • Mucosal barrier integrity ↓30
      • DNAFUT2 non-secretor lowers mucosal fucosylation
    • Autonomic recovery ↓20
      • WearableShort sleep window
    • Inflammatory signalling ↑15
      • WearableHRV 31 ms, trending down
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • CYP2D6 Poor metabolizer
      Higher exposure at standard dose
    Microbiome
    Shannon diversity 4.5 · butyrate capacity 75/100
    • Akkermansia muciniphilaNormal
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisNormal
    • Bifidobacterium longumNormal
    • EnterobacteriaceaeHigh
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    29 ms
    Sleep
    6.3 h
    Steps
    6,974
    Resting HR
    71 bpm
    Daily log: GI score 38, nutritional resilience 52, adherence 95.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Keep fibre steady; no new sources this week
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • Keep the current walking rhythm
    • Protect a 7.5-hour sleep window; screens off 30 minutes before
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0180452%S19AD-05improved61
    P-0154130%S09AD-05no change43
    P-0137728%S11AD-05no change42
    P-0148327%S14AD-05no change35
    P-0167927%S12AD-05no change39
    P-0168930%S13BR-03no change50
    P-0132928%S08BR-03improved79
    P-0135028%S19BR-03no change34
    P-0149527%S07BR-03improved85
    P-0167727%S05BR-03no change86
    P-0143041%S05CR-01improved54
    P-0137131%S06CR-01improved63