Patient P-01646

Synthetic patientNBL-101 · Day 97 · 65–74 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

79%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 54 GI-04 recommended — GI Support Protocol GI-04
Day 55 Patient accepted — Started GI-04 in the companion
Day 63 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 49.

Primary contributors, last 14 days

Toxicity+12
GI instability-9
Inflammatory activity-3
Nutritional resilience-2
Treatment adherence-2

What helped?

GI Support Protocol GI-04Day 54
Result: no meaningful change

LIFE OS recommendation

Dietary Support Protocol NP-02

58%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

63.1/100

improving · -4.6 vs previous 14 d

Toxicity

Blood

56.5/100

stable · +1.5 vs previous 14 d

Sleep quality

Wearable

25/100

worsening · -1.7 vs previous 14 d

Energy level

Daily log

2.4/10

improving · +0.2 vs previous 14 d

Stress level

Daily log

6.3/10

stable · -0.0 vs previous 14 d

Steps

Wearable

5,460

improving · +416 vs previous 14 d

Adherence

Companion

42.2 %

worsening · -9.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 19 from the failing basin, 71 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 70%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 70%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 70%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep histamine low
GI +3.8 next day on high-intake days · n 28
Keep fat low
GI +3.4 next day on high-intake days · n 25
Keep simple carbs low
GI +2.5 next day on high-intake days · n 23

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+3.8detractor · 95%
Dietary fat load
+3.4detractor · 95%
Simple carbohydrates
+2.5detractor · 83%
Spicy / capsaicin
+2.2detractor · 72%
Alcohol
+1.8detractor · 58%
Insoluble fibre
+0.9no signal · 21%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 64
Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 63 and rising
- WearableSleep 6.0 h, below personal baseline
Autonomic recovery ↓45
- WearableResting HR 86 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 57

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.8 · butyrate capacity 32/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 45 ms
Sleep: 6.2 h
Steps: 5,731
Resting HR: 85 bpm

Daily log: GI score 63, nutritional resilience 35, adherence 42.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01732	59%	S14	ME-01	improved	45
P-01735	59%	S14	—	—	40
P-01463	54%	S14	NP-02	no change	41
P-01564	54%	S14	ME-01	improved	39
P-01656	54%	S14	ME-01	improved	41
P-01728	51%	S14	SC-12	improved	41
P-01751	51%	S14	ME-01	improved	48
P-01897	51%	S14	ME-01	improved	43
P-01605	50%	S14	ME-01	improved	41
P-01843	50%	S14	SC-12	no change	45
P-01834	49%	S14	NP-02	improved	44
P-01572	48%	S14	GI-04	worsened	41