Patient P-01674

Synthetic patientNBL-101 · Day 110 · 65–74 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Deteriorating

GI state

Improving

Inflammatory state

Stable

Nutritional resilience

Stable

Discontinuation risk

57%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 51 GI-04 recommended — GI Support Protocol GI-04
Day 52 Patient accepted — Started GI-04 in the companion
Day 54 SC-12 recommended — Supportive Compound SC-12
Day 55 Patient accepted — Started SC-12 in the companion
Day 60 GI symptom burden −32% vs expected — GI Support Protocol GI-04
Day 61 No meaningful change — Supportive Compound SC-12
Day 66 Tolerance state changed — Unstable → Improving
Day 70 ME-01 recommended — Monitoring Escalation ME-01
Day 71 Patient accepted — Started ME-01 in the companion
Day 74 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 48.

Primary contributors, last 14 days

Toxicity+8
GI instability-7
Treatment adherence+5
Inflammatory activity-2

What helped?

GI Support Protocol GI-04Day 51
Result: symptom burden −32%
Supportive Compound SC-12Day 54
Result: no meaningful change
Monitoring Escalation ME-01Day 70
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

52%

probability of meaningful tolerance improvement

284 similar trajectories
68% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

39.7/100

improving · -6.4 vs previous 14 d

Toxicity

Blood

45.7/100

worsening · +12.3 vs previous 14 d

Sleep quality

Wearable

42.5/100

improving · +5.8 vs previous 14 d

Energy level

Daily log

4.4/10

stable · -0.1 vs previous 14 d

Stress level

Daily log

5.5/10

stable · +0.2 vs previous 14 d

Steps

Wearable

5,268

improving · +259 vs previous 14 d

Adherence

Companion

55.7 %

stable · -0.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 42 from the failing basin, 45 from restoration.

Would help

NP-02 Dietary Support Protocol
63% improved among 63 similar · onset 10 d · confidence 59%
CR-01 Clinician Review
100% improved among 7 similar · onset 5 d · confidence 59%

Would not help

SC-12 Supportive Compound
already tried, no meaningful change
Keep fat low
GI +5.8 next day on high-intake days · n 20
Keep simple carbs low
GI +5 next day on high-intake days · n 11

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+5.8detractor · 95%
Simple carbohydrates
+5detractor · 93%
Histamine load
-1.6no signal · 34%
Spicy / capsaicin
-0.7no signal · 17%
Insoluble fibre
+0.6no signal · 15%
Alcohol
-0.5no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↓85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 47
- WearableHRV 35 ms, trending down
Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 25/100
- MicrobiomeF. prausnitzii depleted
Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
Drug metabolism and exposure ↑20
- BloodToxicity index 46

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.5 · butyrate capacity 25/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 37 ms
Sleep: 7.1 h
Steps: 3,296
Resting HR: 64 bpm

Daily log: GI score 40, nutritional resilience 50, adherence 56.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01804	26%	S19	AD-05	improved	61
P-01377	25%	S11	AD-05	no change	42
P-01483	25%	S14	AD-05	no change	35
P-01689	26%	S13	BR-03	no change	50
P-01371	32%	S06	CR-01	improved	63
P-01708	30%	S07	CR-01	improved	59
P-01442	29%	S13	CR-01	improved	61
P-01696	29%	S20	CR-01	improved	59
P-01835	29%	S17	CR-01	improved	56
P-01388	28%	S17	CR-01	improved	59
P-01430	27%	S05	CR-01	improved	54
P-01767	26%	S14	DT-01	no change	63