Patient P-01675

Synthetic patientNBL-101 · Day 109 · 65–74 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Stable

GI state

Stable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

73%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −25% vs expected — Dietary Support Protocol NP-02
Day 48 Tolerance state changed — Unstable → Improving
Day 52 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 54 GI-04 recommended — GI Support Protocol GI-04
Day 55 Patient accepted — Started GI-04 in the companion
Day 63 No meaningful change — GI Support Protocol GI-04
Day 63 ME-01 recommended — Monitoring Escalation ME-01
Day 64 Patient accepted — Started ME-01 in the companion
Day 67 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 52.

Primary contributors, last 14 days

Treatment adherence-9
Inflammatory activity+6
GI instability+2
Toxicity+2

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −25%
GI Support Protocol GI-04Day 54
Result: no meaningful change
Monitoring Escalation ME-01Day 63
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Supportive Compound SC-12

67%

probability of meaningful tolerance improvement

284 similar trajectories
81% showed improvement
median effect visible after 6 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

56/100

stable · +1.3 vs previous 14 d

Toxicity

Blood

45.7/100

stable · +1.8 vs previous 14 d

Sleep quality

Wearable

40.4/100

stable · -1.4 vs previous 14 d

Energy level

Daily log

3.1/10

worsening · -0.5 vs previous 14 d

Stress level

Daily log

6.7/10

worsening · +0.2 vs previous 14 d

Steps

Wearable

5,182

stable · +133 vs previous 14 d

Adherence

Companion

44.9 %

stable · -1.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 21 from the failing basin, 66 from restoration.

Would help

SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 68%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 68%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep fat low
GI +4.8 next day on high-intake days · n 19
Keep simple carbs low
GI +3.7 next day on high-intake days · n 15
Keep fibre low
GI +3.5 next day on high-intake days · n 23

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+4.8detractor · 90%
Simple carbohydrates
+3.7detractor · 78%
Insoluble fibre
+3.5detractor · 75%
Histamine load
-1.4no signal · 24%
Spicy / capsaicin
+0.8no signal · 15%
Alcohol
+0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 56 and rising
Autonomic recovery ↑45
- WearableResting HR 81 bpm
- WearableShort sleep window
Inflammatory signalling ↑25
- BloodInflammatory load index 58
Butyrate / short-chain fatty acid production ↓20
- Daily logFibre intake low in recent food logs
Drug metabolism and exposure ↑20
- BloodToxicity index 46

DNA

Fictional pharmacogenomic panel

CYP2D6 Intermediate metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.8 · butyrate capacity 45/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 57 ms
Sleep: 6.2 h
Steps: 6,241
Resting HR: 80 bpm

Daily log: GI score 56, nutritional resilience 41, adherence 45.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01327	38%	S01	GI-04	improved	56
P-01813	37%	S01	NP-02	no change	40
P-01688	34%	S01	GI-04	improved	40
P-01310	28%	S01	—	—	57
P-01877	23%	S01	CR-01	improved	67
P-01731	20%	S01	ME-01	improved	32
P-01452	37%	S02	GI-04	improved	46
P-01635	36%	S02	GI-04	improved	49
P-01459	27%	S02	—	—	51
P-01498	21%	S02	—	—	56
P-01499	20%	S02	—	—	65
P-01741	20%	S02	—	—	55