Patient P-01678

Synthetic patientNBL-101 · Day 116 · 45–54 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Favorable

Inflammatory state

Stable

Nutritional resilience

Declining

Discontinuation risk

55%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −17% vs expected — Dietary Support Protocol NP-02
Day 46 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 48 Tolerance state changed — Unstable → Improving
Day 53 SC-12 recommended — Supportive Compound SC-12
Day 54 Patient declined — Not now
Day 56 GI-04 recommended — GI Support Protocol GI-04
Day 57 Patient accepted — Started GI-04 in the companion
Day 65 GI symptom burden −38% vs expected — GI Support Protocol GI-04
Day 71 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 46.

Primary contributors, last 14 days

Nutritional resilience-7
Inflammatory activity-3
Treatment adherence-2

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −17%
Supportive Compound SC-12Day 53
Declined by patient
GI Support Protocol GI-04Day 56
Result: symptom burden −38%

LIFE OS recommendation

Supportive Compound SC-12

65%

probability of meaningful tolerance improvement

284 similar trajectories
85% showed improvement
median effect visible after 6 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

36.3/100

stable · +1.1 vs previous 14 d

Toxicity

Blood

43.9/100

worsening · +6.7 vs previous 14 d

Sleep quality

Wearable

24.9/100

worsening · -1.9 vs previous 14 d

Energy level

Daily log

3/10

worsening · -0.4 vs previous 14 d

Stress level

Daily log

6/10

stable · +0.1 vs previous 14 d

Steps

Wearable

5,939

stable · -103 vs previous 14 d

Adherence

Companion

55.2 %

stable · +1.0 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 46 from the failing basin, 43 from restoration.

Good elements to keep

GI Support Protocol GI-04
intervention · steering +63.5
Dietary Support Protocol NP-02
intervention · steering +26.2

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
FUT2 non-secretor
hidden · steering -10.6
Dietary fat load
perturbation · steering -9.1
Histamine load
perturbation · steering -7.8
Dietary fat load
detractor · GI +5.4 next day
Histamine load
detractor · GI +4.9 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+5.4detractor · 95%
Histamine load
+4.9detractor · 95%
Simple carbohydrates
+4.4detractor · 95%
Insoluble fibre
+3.8detractor · 95%
Alcohol
+1.3no signal · 27%
Spicy / capsaicin
-0.4no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓70
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 5.5 h, below personal baseline
Inflammatory signalling ↓25
- BloodInflammatory load index 42
Drug metabolism and exposure ↑20
- BloodToxicity index 44
Autonomic recovery ↓20
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.6 · butyrate capacity 32/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 48 ms
Sleep: 5.8 h
Steps: 6,149
Resting HR: 65 bpm

Daily log: GI score 36, nutritional resilience 49, adherence 55.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01688	41%	S01	GI-04	improved	40
P-01327	36%	S01	GI-04	improved	56
P-01310	30%	S01	—	—	57
P-01813	28%	S01	NP-02	no change	40
P-01846	28%	S01	—	—	37
P-01731	27%	S01	ME-01	improved	32
P-01821	27%	S01	—	—	58
P-01823	27%	S01	—	—	57
P-01455	26%	S01	GI-04	improved	61
P-01604	26%	S01	—	—	71
P-01635	47%	S02	GI-04	improved	49
P-01452	35%	S02	GI-04	improved	46