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Patient P-01680

Synthetic patientNBL-101 · Day 91 · 45–54 · F · baseline S08Steering view · 3DOpen companion preview
Therapy response
Unstable
Tolerance
Improving
GI state
Favorable
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
17%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S08
  2. Day 10 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 10.

Primary contributors, last 14 days
  • Toxicity-6
  • Nutritional resilience+4
  • GI instability+3
  • Treatment adherence+2

What helped?

No interventions yet.

    LIFE OS recommendation
    No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    18.1/100
    worsening · +3.8 vs previous 14 d
    Toxicity
    Blood
    15.2/100
    improving · -0.9 vs previous 14 d
    Sleep quality
    Wearable
    57.2/100
    stable · -0.3 vs previous 14 d
    Energy level
    Daily log
    6/10
    stable · -0.2 vs previous 14 d
    Stress level
    Daily log
    3.4/10
    stable · +0.1 vs previous 14 d
    Steps
    Wearable
    6,435
    worsening · -439 vs previous 14 d
    Adherence
    Companion
    88.7 %
    stable · -0.8 vs previous 14 d
    This trajectory is doing well — what to keep, what to watch
    Steering view →

    Heading towards restoration · 70 from the failing basin, 44 from restoration.

    Good elements to keep
    • Butyrate producers intact
      hidden · steering +7.5
    Main detractors to watch
    • FUT2 non-secretor
      hidden · steering -10.6
    • Histamine load
      perturbation · steering -8.3
    • Bacteroides fragilis elevated
      hidden · steering -7.4
    • IL6 high-expression variant
      hidden · steering -7.3
    • Histamine load
      detractor · GI +4.4 next day
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +4.4detractor · 95%
    • Dietary fat load
      +1no signal · 27%
    • Insoluble fibre
      -0.7no signal · 19%
    • Spicy / capsaicin
      +0.7no signal · 18%
    • Simple carbohydrates
      -0.5no signal · 15%
    • Alcohol
      -0.2no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Mucosal barrier integrity ↓60
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • MicrobiomeAkkermansia low → thinner mucus layer
    • Inflammatory signalling ↓45
      • DNAIL6 -174 variant raises baseline inflammatory tone
      • MicrobiomeBacteroides fragilis expansion
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • IL6 -174 G/C
      Higher inflammatory tone
    • CYP2D6 Intermediate metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 4.5 · butyrate capacity 60/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisHigh
    • Bifidobacterium longumNormal
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    58 ms
    Sleep
    7.1 h
    Steps
    6,505
    Resting HR
    63 bpm
    Daily log: GI score 18, nutritional resilience 67, adherence 89.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Keep fibre steady; no new sources this week
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • Keep the current walking rhythm
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0173152%S01ME-01improved32
    P-0177344%S05AD-05improved27
    P-0131340%S01BR-03improved32
    P-0132037%S09HY-01improved38
    P-0161837%S10GI-04improved39
    P-0137434%S08HY-01improved49
    P-0186133%S12HY-01improved47
    P-0138532%S06HY-01improved50
    P-0175232%S20DT-01improved50
    P-0140531%S14SC-12improved44
    P-0155531%S06GI-04improved56
    P-0134230%S11DT-01improved48