Patient P-01690

Synthetic patientNBL-101 · Day 106 · 25–34 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

96%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 52 GI-04 recommended — GI Support Protocol GI-04
Day 53 Patient declined — Not now

What changed?

Trajectory began diverging from predicted response on Day 47.

Primary contributors, last 14 days

GI instability+4
Nutritional resilience+4
Treatment adherence-4
Inflammatory activity+3
Toxicity+2

What helped?

GI Support Protocol GI-04Day 52
Declined by patient

LIFE OS recommendation

GI Support Protocol GI-04

92%

probability of meaningful tolerance improvement

284 similar trajectories
84% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

70.2/100

stable · +0.4 vs previous 14 d

Toxicity

Blood

46/100

improving · -6.8 vs previous 14 d

Sleep quality

Wearable

2.1/100

worsening · -3.3 vs previous 14 d

Energy level

Daily log

1.5/10

stable · +0.0 vs previous 14 d

Stress level

Daily log

8/10

stable · +0.2 vs previous 14 d

Steps

Wearable

405

worsening · -194 vs previous 14 d

Adherence

Companion

43.3 %

stable · -0.6 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 24 from the failing basin, 72 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 123 similar · onset 8 d · confidence 97%
ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 76%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 76%
More fibre
GI -2.7 next day on high-intake days · n 21

Would not help

Keep histamine low
GI +4.9 next day on high-intake days · n 25
Keep simple carbs low
GI +2.7 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+4.9detractor · 95%
Simple carbohydrates
+2.7detractor · 57%
Insoluble fibre
-2.7supporter · 56%
Dietary fat load
+0.4no signal · 15%
Alcohol
+0.4no signal · 15%
Spicy / capsaicin
+0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 70 and rising
- WearableSleep 4.5 h, below personal baseline
Autonomic recovery ↑65
- WearableResting HR 79 bpm
- Wearable405 steps/day
- WearableShort sleep window
Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 59
- WearableHRV 24 ms, trending down
Butyrate / short-chain fatty acid production ↓20
- Daily logFibre intake low in recent food logs
Drug metabolism and exposure ↑20
- BloodToxicity index 46

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Rapid metabolizer
Expected exposure

Microbiome

Shannon diversity 1.9 · butyrate capacity 45/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 22 ms
Sleep: 4.8 h
Steps: 537
Resting HR: 80 bpm

Daily log: GI score 70, nutritional resilience 33, adherence 43.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01843	52%	S14	SC-12	no change	45
P-01751	48%	S14	ME-01	improved	48
P-01760	48%	S14	—	—	42
P-01656	47%	S14	ME-01	improved	41
P-01826	47%	S10	—	—	42
P-01463	46%	S14	NP-02	no change	41
P-01732	46%	S14	ME-01	improved	45
P-01762	46%	S14	NP-02	no change	40
P-01595	45%	S14	GI-04	no change	51
P-01646	45%	S14	GI-04	no change	42
P-01872	45%	S14	NP-02	improved	47
P-01311	44%	S14	ME-01	improved	49