Patient P-01696

Synthetic patientNBL-101 · Day 108 · 55–64 · M · baseline S20Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Improving

Inflammatory state

Unstable

Nutritional resilience

Stable

Discontinuation risk

52%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S20
Day 82 CR-01 recommended — Clinician Review CR-01
Day 83 Patient accepted — Started CR-01 in the companion
Day 86 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 88 Deterioration detected before clinical escalation — Clinician Review CR-01

What changed?

Trajectory began diverging from predicted response on Day 86.

Primary contributors, last 14 days

Treatment adherence-12
GI instability-8
Inflammatory activity+5
Toxicity+4

What helped?

Clinician Review CR-01Day 82
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

54%

probability of meaningful tolerance improvement

284 similar trajectories
85% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

49.1/100

worsening · +13.3 vs previous 14 d

Toxicity

Blood

52.6/100

worsening · +8.2 vs previous 14 d

Sleep quality

Wearable

42.9/100

worsening · -4.4 vs previous 14 d

Energy level

Daily log

3.4/10

worsening · -1.3 vs previous 14 d

Stress level

Daily log

7.3/10

worsening · +1.3 vs previous 14 d

Steps

Wearable

1,956

worsening · -772 vs previous 14 d

Adherence

Companion

65.4 %

worsening · -13.7 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 39 from the failing basin, 54 from restoration.

Good elements to keep

Clinician Review CR-01
intervention · steering +9.9

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
FUT2 non-secretor
hidden · steering -10.6
Histamine load
perturbation · steering -9
Low microbial diversity
hidden · steering -7.7
Histamine load
detractor · GI +4.7 next day
Dietary fat load
detractor · GI +4 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+4.7detractor · 95%
Dietary fat load
+4detractor · 95%
Simple carbohydrates
+3detractor · 91%
Spicy / capsaicin
+1.4no signal · 42%
Insoluble fibre
+0.9no signal · 24%
Alcohol
+0.2no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 62
- WearableHRV 25 ms, trending down
Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 49 and rising
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 23/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↓45
- WearableResting HR 74 bpm
- Wearable1,956 steps/day
Drug metabolism and exposure ↑20
- BloodToxicity index 53

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.7 · butyrate capacity 23/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 26 ms
Sleep: 7.1 h
Steps: 1,256
Resting HR: 73 bpm

Daily log: GI score 49, nutritional resilience 42, adherence 65.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01804	26%	S19	AD-05	improved	61
P-01442	49%	S13	CR-01	improved	61
P-01388	45%	S17	CR-01	improved	59
P-01371	43%	S06	CR-01	improved	63
P-01835	40%	S17	CR-01	improved	56
P-01877	37%	S01	CR-01	improved	67
P-01708	34%	S07	CR-01	improved	59
P-01430	25%	S05	CR-01	improved	54
P-01342	25%	S11	DT-01	improved	48
P-01346	23%	S12	DT-01	improved	52
P-01699	43%	S04	GI-04	improved	69
P-01725	39%	S18	GI-04	no change	56