Patient P-01702

Synthetic patientNBL-101 · Day 112 · 35–44 · M · baseline S04Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Improving

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S04
Day 26 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 26.

Primary contributors, last 14 days

GI instability-27
Inflammatory activity-17
Nutritional resilience+9
Treatment adherence+7
Toxicity-6

What helped?

No interventions yet.

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

0/100

improving · -2.6 vs previous 14 d

Toxicity

Blood

26.2/100

worsening · +5.5 vs previous 14 d

Sleep quality

Wearable

53.5/100

stable · -0.6 vs previous 14 d

Energy level

Daily log

6.3/10

worsening · -0.3 vs previous 14 d

Stress level

Daily log

3.7/10

stable · -0.1 vs previous 14 d

Steps

Wearable

5,006

improving · +358 vs previous 14 d

Adherence

Companion

91.4 %

improving · +7.3 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 84 from the failing basin, 57 from restoration.

Good elements to keep

Butyrate producers intact
hidden · steering +7.5

Main detractors to watch

FUT2 non-secretor
hidden · steering -10.6
Histamine load
perturbation · steering -8.3
Bacteroides fragilis elevated
hidden · steering -7.4
Poor-sleep week
perturbation · steering -3
Histamine load
detractor · GI +5.2 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+5.2detractor · 95%
Simple carbohydrates
+2no signal · 34%
Alcohol
-1.9no signal · 36%
Insoluble fibre
+1.5no signal · 32%
Dietary fat load
+1.2no signal · 23%
Spicy / capsaicin
-0.8no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 4.2 · butyrate capacity 80/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 47 ms
Sleep: 6.4 h
Steps: 4,172
Resting HR: 71 bpm

Daily log: GI score 0, nutritional resilience 65, adherence 91.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Keep fibre steady; no new sources this week
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01773	50%	S05	AD-05	improved	27
P-01848	32%	S05	AD-05	no change	23
P-01679	31%	S12	AD-05	no change	39
P-01483	30%	S14	AD-05	no change	35
P-01377	29%	S11	AD-05	no change	42
P-01541	27%	S09	AD-05	no change	43
P-01804	22%	S19	AD-05	improved	61
P-01450	33%	S09	BR-03	no change	36
P-01313	32%	S01	BR-03	improved	32
P-01350	30%	S19	BR-03	no change	34
P-01468	29%	S06	BR-03	no change	41
P-01689	24%	S13	BR-03	no change	50