Patient P-01729

Synthetic patientNBL-101 · Day 92 · 35–44 · F · baseline S08Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Favorable

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Favorable

Discontinuation risk

24%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S08

What changed?

Trajectory is tracking the baseline prediction.

Primary contributors, last 14 days

GI instability+5
Inflammatory activity+5
Nutritional resilience-2
Treatment adherence-2

What helped?

No interventions yet.

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

27.2/100

stable · +0.0 vs previous 14 d

Toxicity

Blood

21/100

worsening · +1.0 vs previous 14 d

Sleep quality

Wearable

44.2/100

stable · -1.7 vs previous 14 d

Energy level

Daily log

5/10

stable · +0.0 vs previous 14 d

Stress level

Daily log

3.2/10

stable · -0.0 vs previous 14 d

Steps

Wearable

9,321

stable · +316 vs previous 14 d

Adherence

Companion

92.6 %

stable · -0.1 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 68 from the failing basin, 19 from restoration.

Good elements to keep

Butyrate producers intact
hidden · steering +7.5

Main detractors to watch

FUT2 non-secretor
hidden · steering -10.6
Bacteroides fragilis elevated
hidden · steering -7.4
IL6 high-expression variant
hidden · steering -7.3
Histamine load
perturbation · steering -5.8
Histamine load
detractor · GI +3.2 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+3.2detractor · 95%
Insoluble fibre
+1.3no signal · 35%
Dietary fat load
+1no signal · 35%
Spicy / capsaicin
+0.6no signal · 20%
Alcohol
-0.4no signal · 15%
Simple carbohydrates
+0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑45
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
Autonomic recovery ↑45
- WearableResting HR 75 bpm
- WearableShort sleep window
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 3.1 · butyrate capacity 46/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 63 ms
Sleep: 6.2 h
Steps: 9,228
Resting HR: 75 bpm

Daily log: GI score 27, nutritional resilience 61, adherence 93.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	35%	S11	AD-05	no change	42
P-01804	35%	S19	AD-05	improved	61
P-01541	34%	S09	AD-05	no change	43
P-01483	31%	S14	AD-05	no change	35
P-01679	30%	S12	AD-05	no change	39
P-01689	38%	S13	BR-03	no change	50
P-01329	32%	S08	BR-03	improved	79
P-01677	31%	S05	BR-03	no change	86
P-01468	30%	S06	BR-03	no change	41
P-01350	29%	S19	BR-03	no change	34
P-01313	28%	S01	BR-03	improved	32
P-01450	28%	S09	BR-03	no change	36