Patient P-01731

Synthetic patientNBL-101 · Day 109 · 25–34 · F · baseline S01Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Favorable

GI state

Favorable

Inflammatory state

Favorable

Nutritional resilience

Favorable

Discontinuation risk

23%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S01
Day 11 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 53 ME-01 recommended — Monitoring Escalation ME-01
Day 54 Patient accepted — Started ME-01 in the companion
Day 57 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 11.

Primary contributors, last 14 days

Treatment adherence+4
GI instability+3
Toxicity-3
Nutritional resilience+2

What helped?

Monitoring Escalation ME-01Day 53
Result: deterioration detected before clinical escalation

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

25.1/100

improving · -3.4 vs previous 14 d

Toxicity

Blood

21.1/100

improving · -4.1 vs previous 14 d

Sleep quality

Wearable

50.2/100

improving · +3.7 vs previous 14 d

Energy level

Daily log

4.5/10

improving · +0.5 vs previous 14 d

Stress level

Daily log

3.6/10

improving · -0.5 vs previous 14 d

Steps

Wearable

7,725

stable · +247 vs previous 14 d

Adherence

Companion

87.6 %

stable · -1.6 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 60 from the failing basin, 46 from restoration.

Good elements to keep

Monitoring Escalation ME-01
intervention · steering +10
Butyrate producers intact
hidden · steering +7.5

Main detractors to watch

FUT2 non-secretor
hidden · steering -10.6
Enterobacteriaceae elevated
hidden · steering -7.4
Histamine load
perturbation · steering -4.5
Poor-sleep week
perturbation · steering -3
Histamine load
detractor · GI +2.7 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+2.7detractor · 95%
Simple carbohydrates
+1no signal · 27%
Insoluble fibre
-0.6no signal · 18%
Alcohol
+0.5no signal · 15%
Dietary fat load
-0.2no signal · 15%
Spicy / capsaicin
-0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Autonomic recovery ↑25
- WearableResting HR 76 bpm

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3.7 · butyrate capacity 74/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 64 ms
Sleep: 7.1 h
Steps: 7,913
Resting HR: 75 bpm

Daily log: GI score 25, nutritional resilience 64, adherence 88.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Keep fibre steady; no new sources this week
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01773	39%	S05	AD-05	improved	27
P-01377	38%	S11	AD-05	no change	42
P-01483	35%	S14	AD-05	no change	35
P-01679	35%	S12	AD-05	no change	39
P-01848	34%	S05	AD-05	no change	23
P-01541	32%	S09	AD-05	no change	43
P-01804	25%	S19	AD-05	improved	61
P-01313	38%	S01	BR-03	improved	32
P-01450	37%	S09	BR-03	no change	36
P-01350	34%	S19	BR-03	no change	34
P-01468	32%	S06	BR-03	no change	41
P-01689	30%	S13	BR-03	no change	50