Patient P-01733
Synthetic patientNBL-101 · Day 101 · 55–64 · M · baseline S05Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S05
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 54 SC-12 recommended — Supportive Compound SC-12
- Day 55 Patient accepted — Started SC-12 in the companion
- Day 61 No meaningful change — Supportive Compound SC-12
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- GI instability+13
- Nutritional resilience-12
- Treatment adherence+5
- Inflammatory activity+4
- Toxicity+3
What helped?
- Supportive Compound SC-12Day 54Result: no meaningful change
LIFE OS recommendation
GI Support Protocol GI-04
90%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion68.8/100
stable · +0.5 vs previous 14 d
Toxicity
Blood48.9/100
worsening · +6.0 vs previous 14 d
Sleep quality
Wearable17.2/100
worsening · -2.2 vs previous 14 d
Energy level
Daily log1.8/10
worsening · -0.4 vs previous 14 d
Stress level
Daily log6.5/10
stable · +0.0 vs previous 14 d
Steps
Wearable3,379
improving · +134 vs previous 14 d
Adherence
Companion41.7 %
worsening · -5.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 26 from the failing basin, 71 from restoration.
Would help
Would not help
- SC-12 Supportive Compoundalready tried, no meaningful change
- Keep fat lowGI +5.1 next day on high-intake days · n 24
- Keep histamine lowGI +5 next day on high-intake days · n 25
- Keep alcohol lowGI +4.9 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+5.1detractor · 95%
- Histamine load+5detractor · 95%
- Alcohol+4.9detractor · 95%
- Insoluble fibre-1.4no signal · 29%
- Spicy / capsaicin-1.2no signal · 28%
- Simple carbohydrates-0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 69 and rising
- WearableSleep 5.4 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 36/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓65
- WearableResting HR 80 bpm
- Wearable3,379 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 49
- Inflammatory signalling ↑25
- BloodInflammatory load index 63
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3 · butyrate capacity 36/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 46 ms
- Sleep
- 5.3 h
- Steps
- 1,471
- Resting HR
- 79 bpm
Daily log: GI score 69, nutritional resilience 30, adherence 42.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01377 | 18% | S11 | AD-05 | no change | 42 |
| P-01483 | 18% | S14 | AD-05 | no change | 35 |
| P-01689 | 19% | S13 | BR-03 | no change | 50 |
| P-01708 | 28% | S07 | CR-01 | improved | 59 |
| P-01371 | 25% | S06 | CR-01 | improved | 63 |
| P-01388 | 25% | S17 | CR-01 | improved | 59 |
| P-01835 | 25% | S17 | CR-01 | improved | 56 |
| P-01696 | 24% | S20 | CR-01 | improved | 59 |
| P-01877 | 24% | S01 | CR-01 | improved | 67 |
| P-01442 | 22% | S13 | CR-01 | improved | 61 |
| P-01430 | 19% | S05 | CR-01 | improved | 54 |
| P-01342 | 18% | S11 | DT-01 | improved | 48 |