Patient P-01735
Therapy response
Unstable
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 51 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 51.
Primary contributors, last 14 days
- Toxicity+9
- GI instability-8
- Inflammatory activity-3
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion70.5/100
improving · -8.5 vs previous 14 d
Toxicity
Blood61.8/100
worsening · +4.1 vs previous 14 d
Sleep quality
Wearable28.7/100
improving · +5.4 vs previous 14 d
Energy level
Daily log1.4/10
stable · -0.1 vs previous 14 d
Stress level
Daily log6.8/10
improving · -0.5 vs previous 14 d
Steps
Wearable2,440
improving · +756 vs previous 14 d
Adherence
Companion39.5 %
worsening · -3.1 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 17 from the failing basin, 79 from restoration.
Would help
Would not help
- Keep simple carbs lowGI +4.4 next day on high-intake days · n 15
- Keep histamine lowGI +4.1 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Simple carbohydrates+4.4detractor · 95%
- Histamine load+4.1detractor · 95%
- Alcohol-1.1no signal · 30%
- Spicy / capsaicin+0.5no signal · 15%
- Dietary fat load-0.1no signal · 15%
- Insoluble fibre0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 71 and rising
- Autonomic recovery ↑65
- WearableResting HR 87 bpm
- Wearable2,440 steps/day
- WearableShort sleep window
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓25
- BloodInflammatory load index 68
- Drug metabolism and exposure ↑20
- BloodToxicity index 62
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.5 · butyrate capacity 48/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 42 ms
- Sleep
- 6.8 h
- Steps
- 2,927
- Resting HR
- 86 bpm
Daily log: GI score 71, nutritional resilience 32, adherence 40.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01813 | 37% | S01 | NP-02 | no change | 40 |
| P-01327 | 31% | S01 | GI-04 | improved | 56 |
| P-01310 | 27% | S01 | — | — | 57 |
| P-01688 | 27% | S01 | GI-04 | improved | 40 |
| P-01877 | 23% | S01 | CR-01 | improved | 67 |
| P-01604 | 17% | S01 | — | — | 71 |
| P-01452 | 34% | S02 | GI-04 | improved | 46 |
| P-01635 | 29% | S02 | GI-04 | improved | 49 |
| P-01459 | 25% | S02 | — | — | 51 |
| P-01498 | 18% | S02 | — | — | 56 |
| P-01499 | 17% | S02 | — | — | 65 |
| P-01741 | 17% | S02 | — | — | 55 |