Patient P-01739

Synthetic patientNBL-101 · Day 116 · 65–74 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

96%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 72 ME-01 recommended — Monitoring Escalation ME-01
Day 73 Patient accepted — Started ME-01 in the companion
Day 76 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 45.

Primary contributors, last 14 days

Inflammatory activity+8
GI instability+7
Nutritional resilience-5
Toxicity-5
Treatment adherence-4

What helped?

Monitoring Escalation ME-01Day 72
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

92%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

68.3/100

worsening · +10.2 vs previous 14 d

Toxicity

Blood

46/100

stable · +0.1 vs previous 14 d

Sleep quality

Wearable

16.6/100

worsening · -5.8 vs previous 14 d

Energy level

Daily log

2.2/10

worsening · -0.5 vs previous 14 d

Stress level

Daily log

6.9/10

worsening · +0.4 vs previous 14 d

Steps

Wearable

7,410

worsening · -351 vs previous 14 d

Adherence

Companion

41.5 %

stable · +1.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 20 from the failing basin, 76 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 124 similar · onset 8 d · confidence 97%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 80%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 80%

Would not help

Keep simple carbs low
GI +3.2 next day on high-intake days · n 15
Keep alcohol low
GI +3.1 next day on high-intake days · n 20
Keep fibre low
GI +2.7 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Simple carbohydrates
+3.2detractor · 95%
Alcohol
+3.1detractor · 95%
Insoluble fibre
+2.7detractor · 94%
Dietary fat load
+0.9no signal · 25%
Histamine load
-0.5no signal · 15%
Spicy / capsaicin
-0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 68 and rising
- WearableSleep 5.6 h, below personal baseline
Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 68
- WearableHRV 21 ms, trending down
Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 46
Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑45
- WearableResting HR 84 bpm
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.6 · butyrate capacity 48/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 21 ms
Sleep: 5.6 h
Steps: 6,870
Resting HR: 85 bpm

Daily log: GI score 68, nutritional resilience 30, adherence 42.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01604	18%	S01	—	—	71
P-01386	18%	S13	—	—	70
P-01352	18%	S20	—	—	70
P-01699	24%	S04	GI-04	improved	69
P-01508	18%	S18	—	—	68
P-01509	19%	S17	—	—	68
P-01877	26%	S01	CR-01	improved	67
P-01629	19%	S19	—	—	66
P-01714	22%	S14	GI-04	improved	66
P-01858	30%	S14	NP-02	improved	65
P-01317	19%	S19	—	—	65
P-01643	19%	S17	—	—	65