Patient P-01739
Synthetic patientNBL-101 · Day 116 · 65–74 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 72 ME-01 recommended — Monitoring Escalation ME-01
- Day 73 Patient accepted — Started ME-01 in the companion
- Day 76 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- Inflammatory activity+8
- GI instability+7
- Nutritional resilience-5
- Toxicity-5
- Treatment adherence-4
What helped?
- Monitoring Escalation ME-01Day 72Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion68.3/100
worsening · +10.2 vs previous 14 d
Toxicity
Blood46/100
stable · +0.1 vs previous 14 d
Sleep quality
Wearable16.6/100
worsening · -5.8 vs previous 14 d
Energy level
Daily log2.2/10
worsening · -0.5 vs previous 14 d
Stress level
Daily log6.9/10
worsening · +0.4 vs previous 14 d
Steps
Wearable7,410
worsening · -351 vs previous 14 d
Adherence
Companion41.5 %
stable · +1.5 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 20 from the failing basin, 76 from restoration.
Would help
Would not help
- Keep simple carbs lowGI +3.2 next day on high-intake days · n 15
- Keep alcohol lowGI +3.1 next day on high-intake days · n 20
- Keep fibre lowGI +2.7 next day on high-intake days · n 17
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Simple carbohydrates+3.2detractor · 95%
- Alcohol+3.1detractor · 95%
- Insoluble fibre+2.7detractor · 94%
- Dietary fat load+0.9no signal · 25%
- Histamine load-0.5no signal · 15%
- Spicy / capsaicin-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 68 and rising
- WearableSleep 5.6 h, below personal baseline
- Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 68
- WearableHRV 21 ms, trending down
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 46
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 84 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.6 · butyrate capacity 48/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 21 ms
- Sleep
- 5.6 h
- Steps
- 6,870
- Resting HR
- 85 bpm
Daily log: GI score 68, nutritional resilience 30, adherence 42.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01813 | 48% | S01 | NP-02 | no change | 40 |
| P-01327 | 35% | S01 | GI-04 | improved | 56 |
| P-01688 | 30% | S01 | GI-04 | improved | 40 |
| P-01310 | 29% | S01 | — | — | 57 |
| P-01877 | 26% | S01 | CR-01 | improved | 67 |
| P-01821 | 19% | S01 | — | — | 58 |
| P-01823 | 19% | S01 | — | — | 57 |
| P-01604 | 18% | S01 | — | — | 71 |
| P-01695 | 18% | S01 | — | — | 30 |
| P-01635 | 32% | S02 | GI-04 | improved | 49 |
| P-01452 | 29% | S02 | GI-04 | improved | 46 |
| P-01459 | 28% | S02 | — | — | 51 |