Patient P-01751
Therapy response
Improving
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
95%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 67 ME-01 recommended — Monitoring Escalation ME-01
- Day 68 Patient accepted — Started ME-01 in the companion
- Day 71 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- GI instability-7
- Inflammatory activity-5
- Nutritional resilience+3
- Toxicity+3
- Treatment adherence+2
What helped?
- Monitoring Escalation ME-01Day 67Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
89%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 62
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 55
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 33/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 87 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓20
- Daily logGI symptom score 62 and rising
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2 · butyrate capacity 33/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 6.2 h
- Steps
- 4,348
- Resting HR
- 87 bpm
Daily log: GI score 62, nutritional resilience 37, adherence 45.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01813 | 43% | S01 | NP-02 | no change | 40 |
| P-01327 | 39% | S01 | GI-04 | improved | 56 |
| P-01310 | 29% | S01 | — | — | 57 |
| P-01688 | 29% | S01 | GI-04 | improved | 40 |
| P-01877 | 24% | S01 | CR-01 | improved | 67 |
| P-01821 | 19% | S01 | — | — | 58 |
| P-01604 | 18% | S01 | — | — | 71 |
| P-01635 | 32% | S02 | GI-04 | improved | 49 |
| P-01452 | 31% | S02 | GI-04 | improved | 46 |
| P-01459 | 25% | S02 | — | — | 51 |
| P-01498 | 18% | S02 | — | — | 56 |
| P-01499 | 18% | S02 | — | — | 65 |