Patient P-01777

Synthetic patientNBL-101 · Day 98 · 45–54 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Unstable

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

88%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 47 SC-12 recommended — Supportive Compound SC-12
Day 48 Patient accepted — Started SC-12 in the companion
Day 50 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 54 GI symptom burden −21% vs expected — Supportive Compound SC-12
Day 60 Tolerance state changed — Unstable → Improving
Day 66 ME-01 recommended — Monitoring Escalation ME-01
Day 67 Patient accepted — Started ME-01 in the companion
Day 70 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 50.

Primary contributors, last 14 days

Nutritional resilience+11
Inflammatory activity-9
Toxicity-5
GI instability+3
Treatment adherence-2

What helped?

Supportive Compound SC-12Day 47
Result: symptom burden −21%
Monitoring Escalation ME-01Day 66
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

89%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

58.3/100

improving · -6.5 vs previous 14 d

Toxicity

Blood

37.3/100

stable · -1.5 vs previous 14 d

Sleep quality

Wearable

39.8/100

improving · +4.4 vs previous 14 d

Energy level

Daily log

2.8/10

improving · +0.3 vs previous 14 d

Stress level

Daily log

5.6/10

improving · -0.5 vs previous 14 d

Steps

Wearable

7,810

improving · +469 vs previous 14 d

Adherence

Companion

49.7 %

worsening · -7.8 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 31 from the failing basin, 59 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 124 similar · onset 8 d · confidence 92%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 72%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 72%

Would not help

Keep fat low
GI +5.2 next day on high-intake days · n 24
Keep histamine low
GI +4.3 next day on high-intake days · n 24
Keep simple carbs low
GI +3.1 next day on high-intake days · n 19

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+5.2detractor · 95%
Histamine load
+4.3detractor · 95%
Simple carbohydrates
+3.1detractor · 78%
Alcohol
-1.7no signal · 37%
Insoluble fibre
+0.5no signal · 15%
Spicy / capsaicin
-0.5no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 58 and rising
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 22/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 47

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.7 · butyrate capacity 22/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 40 ms
Sleep: 6.9 h
Steps: 7,554
Resting HR: 72 bpm

Daily log: GI score 58, nutritional resilience 49, adherence 50.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	21%	S11	AD-05	no change	42
P-01483	21%	S14	AD-05	no change	35
P-01708	31%	S07	CR-01	improved	59
P-01371	28%	S06	CR-01	improved	63
P-01835	27%	S17	CR-01	improved	56
P-01388	26%	S17	CR-01	improved	59
P-01696	26%	S20	CR-01	improved	59
P-01442	25%	S13	CR-01	improved	61
P-01877	25%	S01	CR-01	improved	67
P-01430	22%	S05	CR-01	improved	54
P-01767	22%	S14	DT-01	no change	63
P-01342	21%	S11	DT-01	improved	48