Patient P-01782

Synthetic patientNBL-101 · Day 100 · 65–74 · M · baseline S14Open companion preview

Therapy response

Stable

Tolerance

Favorable

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Declining

Discontinuation risk

85%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 No meaningful change — Dietary Support Protocol NP-02
Day 48 SC-12 recommended — Supportive Compound SC-12
Day 49 Patient accepted — Started SC-12 in the companion
Day 51 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 55 No meaningful change — Supportive Compound SC-12
Day 64 ME-01 recommended — Monitoring Escalation ME-01
Day 65 Patient accepted — Started ME-01 in the companion
Day 68 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 51.

Primary contributors, last 14 days

Nutritional resilience-8
Treatment adherence+5
Inflammatory activity+3
GI instability+2

What helped?

Dietary Support Protocol NP-02Day 31
Result: no meaningful change
Supportive Compound SC-12Day 48
Result: no meaningful change
Monitoring Escalation ME-01Day 64
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

86%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 50
Autonomic recovery ↓45
- WearableResting HR 83 bpm
- Wearable1,468 steps/day

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Intermediate metabolizer
Expected exposure

Microbiome

Shannon diversity 2.5 · butyrate capacity 38/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 39 ms
Sleep: 6.6 h
Steps: 1,762
Resting HR: 84 bpm

Daily log: GI score 53, nutritional resilience 43, adherence 49.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01494	57%	S14	GI-04	improved	42
P-01777	54%	S14	SC-12	improved	43
P-01834	54%	S14	NP-02	improved	44
P-01311	51%	S14	ME-01	improved	49
P-01891	51%	S14	SC-12	improved	41
P-01394	50%	S05	SC-12	improved	44
P-01465	50%	S14	NP-02	improved	56
P-01675	50%	S14	NP-02	improved	38
P-01732	50%	S14	ME-01	improved	45
P-01339	49%	S14	GI-04	improved	54
P-01501	49%	S14	GI-04	improved	45
P-01709	49%	S14	GI-04	improved	43