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Patient P-01794

Synthetic patientNBL-101 · Day 116 · 65–74 · F · baseline S09Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
54%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S09
  2. Day 77 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 77.

Primary contributors, last 14 days
  • Nutritional resilience+5
  • GI instability-4
  • Inflammatory activity-3
  • Toxicity-3
  • Treatment adherence+2

What helped?

No interventions yet.

    LIFE OS recommendation
    GI Support Protocol GI-04
    65%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 83% showed improvement
    • median effect visible after 8 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    58/100
    improving · -4.1 vs previous 14 d
    Toxicity
    Blood
    51.4/100
    worsening · +4.0 vs previous 14 d
    Sleep quality
    Wearable
    58.5/100
    improving · +2.0 vs previous 14 d
    Energy level
    Daily log
    3.5/10
    improving · +0.3 vs previous 14 d
    Stress level
    Daily log
    6/10
    stable · -0.2 vs previous 14 d
    Steps
    Wearable
    6,904
    improving · +360 vs previous 14 d
    Adherence
    Companion
    71.6 %
    worsening · -7.0 vs previous 14 d
    This trajectory is doing well — what to keep, what to watch
    Steering view →

    Heading towards restoration · 32 from the failing basin, 62 from restoration.

    Good elements to keep
    • Daily walks resumed
      perturbation · steering +3.3
    Main detractors to watch
    • Low butyrate capacity
      hidden · steering -17.5
    • Dietary fat load
      perturbation · steering -10.8
    • Bacteroides fragilis elevated
      hidden · steering -7.4
    • Poor-sleep week
      perturbation · steering -3
    • Dietary fat load
      detractor · GI +5.8 next day
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Dietary fat load
      +5.8detractor · 95%
    • Simple carbohydrates
      +1.8no signal · 33%
    • Alcohol
      +0.9no signal · 17%
    • Spicy / capsaicin
      +0.3no signal · 15%
    • Insoluble fibre
      +0.2no signal · 15%
    • Histamine load
      0no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Butyrate / short-chain fatty acid production ↓80
      • MicrobiomeButyrate capacity 29/100
      • MicrobiomeF. prausnitzii depleted
      • Daily logFibre intake low in recent food logs
    • Mucosal barrier integrity ↓50
      • MicrobiomeAkkermansia low → thinner mucus layer
      • Daily logGI symptom score 58 and rising
    • Inflammatory signalling ↓45
      • MicrobiomeBacteroides fragilis expansion
      • BloodInflammatory load index 62
    • Autonomic recovery ↓25
      • WearableResting HR 86 bpm
    • Drug metabolism and exposure ↑20
      • BloodToxicity index 51
    DNA
    Fictional pharmacogenomic panel
    • CYP2D6 Normal metabolizer
      Expected exposure
    • MTHFR C677T
      Reduced folate turnover
    Microbiome
    Shannon diversity 3 · butyrate capacity 29/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiLow
    • Bacteroides fragilisHigh
    • Bifidobacterium longumNormal
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    41 ms
    Sleep
    7.1 h
    Steps
    6,113
    Resting HR
    86 bpm
    Daily log: GI score 58, nutritional resilience 38, adherence 72.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
    • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Track each bowel movement today: time, stool form, urgency, overnight waking
    • Keep the current walking rhythm
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • Electrolyte solution, one sachet after any loose stool
    • Fictional demo item: oral nutrition supplement with lunch

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0131048%S01——57
    P-0187740%S01CR-01improved67
    P-0168830%S01GI-04improved40
    P-0132729%S01GI-04improved56
    P-0181327%S01NP-02no change40
    P-0160423%S01——71
    P-0182323%S01——57
    P-0182122%S01——58
    P-0145941%S02——51
    P-0145236%S02GI-04improved46
    P-0163532%S02GI-04improved49
    P-0149824%S02——56