Patient P-01801

Synthetic patientNBL-101 · Day 113 · 65–74 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Improving

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

96%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 39 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 46 SC-12 recommended — Supportive Compound SC-12
Day 47 Patient accepted — Started SC-12 in the companion
Day 53 GI symptom burden −17% vs expected — Supportive Compound SC-12
Day 59 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 39.

Primary contributors, last 14 days

GI instability+21
Nutritional resilience-16
Inflammatory activity+11
Toxicity-8
Treatment adherence-3

What helped?

Supportive Compound SC-12Day 46
Result: symptom burden −17%

LIFE OS recommendation

GI Support Protocol GI-04

91%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

72.9/100

stable · +1.7 vs previous 14 d

Toxicity

Blood

40.8/100

improving · -4.9 vs previous 14 d

Sleep quality

Wearable

21.3/100

stable · -0.3 vs previous 14 d

Energy level

Daily log

1.5/10

improving · +0.2 vs previous 14 d

Stress level

Daily log

6/10

stable · -0.1 vs previous 14 d

Steps

Wearable

6,106

worsening · -560 vs previous 14 d

Adherence

Companion

39.1 %

worsening · -7.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 20 from the failing basin, 79 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 124 similar · onset 8 d · confidence 95%
ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 69%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 69%

Would not help

Keep fat low
GI +4.2 next day on high-intake days · n 21

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+4.2detractor · 95%
Alcohol
-1.5no signal · 33%
Simple carbohydrates
+1.4no signal · 24%
Insoluble fibre
+1no signal · 27%
Histamine load
+0.1no signal · 15%
Spicy / capsaicin
-0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 39/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 73 and rising
- WearableSleep 5.1 h, below personal baseline
Autonomic recovery ↓45
- WearableResting HR 76 bpm
- WearableShort sleep window
Inflammatory signalling ↑25
- BloodInflammatory load index 66
Drug metabolism and exposure ↑20
- BloodToxicity index 41

DNA

Fictional pharmacogenomic panel

CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 3.2 · butyrate capacity 39/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 52 ms
Sleep: 5.3 h
Steps: 6,859
Resting HR: 75 bpm

Daily log: GI score 73, nutritional resilience 31, adherence 39.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	18%	S11	AD-05	no change	42
P-01689	19%	S13	BR-03	no change	50
P-01350	18%	S19	BR-03	no change	34
P-01708	29%	S07	CR-01	improved	59
P-01388	26%	S17	CR-01	improved	59
P-01696	26%	S20	CR-01	improved	59
P-01877	26%	S01	CR-01	improved	67
P-01371	25%	S06	CR-01	improved	63
P-01835	25%	S17	CR-01	improved	56
P-01442	23%	S13	CR-01	improved	61
P-01430	19%	S05	CR-01	improved	54
P-01342	18%	S11	DT-01	improved	48