Patient P-01824
Therapy response
Unstable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 46 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 46.
Primary contributors, last 14 days
- Treatment adherence-6
- Toxicity-5
- Nutritional resilience-4
- GI instability+3
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
91%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 71 and rising
- WearableSleep 5.1 h, below personal baseline
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 58
- WearableHRV 28 ms, trending down
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 43/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓40
- Wearable1,837 steps/day
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.3 · butyrate capacity 43/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 28 ms
- Sleep
- 5.2 h
- Steps
- 1,712
- Resting HR
- 70 bpm
Daily log: GI score 71, nutritional resilience 29, adherence 43.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01822 | 52% | S14 | — | — | 37 |
| P-01692 | 50% | S14 | NP-02 | improved | 49 |
| P-01760 | 50% | S14 | — | — | 42 |
| P-01813 | 50% | S01 | NP-02 | no change | 40 |
| P-01833 | 50% | S14 | ME-01 | improved | 54 |
| P-01801 | 47% | S14 | SC-12 | improved | 42 |
| P-01872 | 47% | S14 | NP-02 | improved | 47 |
| P-01462 | 46% | S14 | NP-02 | improved | 47 |
| P-01482 | 46% | S14 | GI-04 | improved | 47 |
| P-01496 | 46% | S14 | SC-12 | improved | 46 |
| P-01739 | 46% | S14 | ME-01 | improved | 44 |
| P-01799 | 46% | S19 | NP-02 | no change | 51 |