Patient P-01830
Synthetic patientNBL-101 · Day 120 · 25–34 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 49.
Primary contributors, last 14 days
- Treatment adherence+13
- GI instability+6
- Inflammatory activity-3
- Nutritional resilience-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion69.2/100
stable · +2.0 vs previous 14 d
Toxicity
Blood51.3/100
stable · +0.5 vs previous 14 d
Sleep quality
Wearable9.4/100
worsening · -4.4 vs previous 14 d
Energy level
Daily log1.1/10
stable · -0.0 vs previous 14 d
Stress level
Daily log6.7/10
stable · -0.0 vs previous 14 d
Steps
Wearable7,058
improving · +565 vs previous 14 d
Adherence
Companion49.5 %
worsening · -2.6 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 21 from the failing basin, 74 from restoration.
Would help
Would not help
- Keep fat lowGI +3 next day on high-intake days · n 20
- Keep simple carbs lowGI +2.6 next day on high-intake days · n 20
- Keep histamine lowGI +2.2 next day on high-intake days · n 23
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+3detractor · 95%
- Simple carbohydrates+2.6detractor · 95%
- Histamine load+2.2detractor · 86%
- Spicy / capsaicin+1no signal · 31%
- Alcohol-0.9no signal · 27%
- Insoluble fibre+0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 69 and rising
- WearableSleep 5.0 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 30/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 51
- Inflammatory signalling ↓50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 63
- Autonomic recovery ↓45
- WearableResting HR 84 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.5 · butyrate capacity 30/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 40 ms
- Sleep
- 4.8 h
- Steps
- 6,343
- Resting HR
- 82 bpm
Daily log: GI score 69, nutritional resilience 37, adherence 50.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01813 | 47% | S01 | NP-02 | no change | 40 |
| P-01327 | 37% | S01 | GI-04 | improved | 56 |
| P-01310 | 28% | S01 | — | — | 57 |
| P-01688 | 28% | S01 | GI-04 | improved | 40 |
| P-01877 | 23% | S01 | CR-01 | improved | 67 |
| P-01821 | 19% | S01 | — | — | 58 |
| P-01604 | 18% | S01 | — | — | 71 |
| P-01695 | 18% | S01 | — | — | 30 |
| P-01731 | 18% | S01 | ME-01 | improved | 32 |
| P-01635 | 31% | S02 | GI-04 | improved | 49 |
| P-01452 | 30% | S02 | GI-04 | improved | 46 |
| P-01459 | 25% | S02 | — | — | 51 |