Patient P-01834
Therapy response
Stable
Tolerance
Stable
GI state
Improving
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
86%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 GI symptom burden −18% vs expected — Dietary Support Protocol NP-02
- Day 48 Tolerance state changed — Unstable → Improving
- Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 49.
Primary contributors, last 14 days
- Nutritional resilience-7
- GI instability-4
- Inflammatory activity+4
- Toxicity+2
What helped?
- Dietary Support Protocol NP-02Day 31Result: symptom burden −18%
LIFE OS recommendation
GI Support Protocol GI-04
89%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion54.1/100
stable · +1.6 vs previous 14 d
Toxicity
Blood44.5/100
improving · -5.3 vs previous 14 d
Sleep quality
Wearable18.5/100
worsening · -2.3 vs previous 14 d
Energy level
Daily log2.6/10
improving · +0.2 vs previous 14 d
Stress level
Daily log6.5/10
stable · -0.2 vs previous 14 d
Steps
Wearable3,145
improving · +199 vs previous 14 d
Adherence
Companion47.5 %
improving · +6.1 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 26 from the failing basin, 61 from restoration.
Would help
Would not help
- Keep fat lowGI +4.5 next day on high-intake days · n 18
- Keep histamine lowGI +4.5 next day on high-intake days · n 22
- Keep simple carbs lowGI +3.5 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+4.5detractor · 95%
- Histamine load+4.5detractor · 95%
- Simple carbohydrates+3.5detractor · 95%
- Insoluble fibre+2.9detractor · 82%
- Spicy / capsaicin+2.9detractor · 78%
- Alcohol+0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 54 and rising
- WearableSleep 5.8 h, below personal baseline
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 57
- WearableHRV 37 ms, trending down
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 25/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 45
- Autonomic recovery ↑40
- Wearable3,145 steps/day
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.6 · butyrate capacity 25/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 37 ms
- Sleep
- 6.2 h
- Steps
- 3,632
- Resting HR
- 70 bpm
Daily log: GI score 54, nutritional resilience 37, adherence 48.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01409 | 60% | S14 | SC-12 | improved | 41 |
| P-01656 | 58% | S14 | ME-01 | improved | 41 |
| P-01872 | 56% | S14 | NP-02 | improved | 47 |
| P-01462 | 55% | S14 | NP-02 | improved | 47 |
| P-01494 | 55% | S14 | GI-04 | improved | 42 |
| P-01732 | 55% | S14 | ME-01 | improved | 45 |
| P-01433 | 54% | S14 | GI-04 | improved | 48 |
| P-01394 | 53% | S05 | SC-12 | improved | 44 |
| P-01496 | 53% | S14 | SC-12 | improved | 46 |
| P-01564 | 53% | S14 | ME-01 | improved | 39 |
| P-01777 | 52% | S14 | SC-12 | improved | 43 |
| P-01429 | 51% | S09 | GI-04 | improved | 45 |