Patient P-01842

Synthetic patientNBL-101 · Day 117 · 55–64 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

95%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 37 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 42 GI symptom burden −12% vs expected — Dietary Support Protocol NP-02
Day 48 Tolerance state changed — Unstable → Improving
Day 49 SC-12 recommended — Supportive Compound SC-12
Day 50 Patient accepted — Started SC-12 in the companion
Day 56 No meaningful change — Supportive Compound SC-12
Day 63 ME-01 recommended — Monitoring Escalation ME-01
Day 64 Patient accepted — Started ME-01 in the companion
Day 67 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 37.

Primary contributors, last 14 days

Inflammatory activity+7
Toxicity+5
GI instability+2
Treatment adherence+2

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −12%
Supportive Compound SC-12Day 49
Result: no meaningful change
Monitoring Escalation ME-01Day 63
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

92%

probability of meaningful tolerance improvement

284 similar trajectories
84% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

60.9/100

worsening · +5.3 vs previous 14 d

Toxicity

Blood

50.1/100

worsening · +5.3 vs previous 14 d

Sleep quality

Wearable

38.2/100

worsening · -4.9 vs previous 14 d

Energy level

Daily log

2.5/10

worsening · -0.1 vs previous 14 d

Stress level

Daily log

6.2/10

worsening · +0.3 vs previous 14 d

Steps

Wearable

3,031

stable · -32 vs previous 14 d

Adherence

Companion

45.4 %

stable · +1.2 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 33 from the failing basin, 62 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 123 similar · onset 8 d · confidence 97%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 77%

Would not help

SC-12 Supportive Compound
already tried, no meaningful change
Keep simple carbs low
GI +5.4 next day on high-intake days · n 12
Keep histamine low
GI +5 next day on high-intake days · n 26
Keep fat low
GI +4.2 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Simple carbohydrates
+5.4detractor · 95%
Histamine load
+5detractor · 95%
Dietary fat load
+4.2detractor · 95%
Insoluble fibre
+3.4detractor · 82%
Alcohol
+1.5no signal · 35%
Spicy / capsaicin
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 42/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Autonomic recovery ↓65
- WearableResting HR 81 bpm
- Wearable3,031 steps/day
- WearableShort sleep window
Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 50
Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Intermediate metabolizer
Expected exposure

Microbiome

Shannon diversity 2.7 · butyrate capacity 42/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 48 ms
Sleep: 6.2 h
Steps: 1,929
Resting HR: 82 bpm

Daily log: GI score 61, nutritional resilience 40, adherence 45.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01339	52%	S14	GI-04	improved	54
P-01438	52%	S14	GI-04	improved	56
P-01668	52%	S14	GI-04	no change	58
P-01845	51%	S14	NP-02	improved	47
P-01412	50%	S14	NP-02	improved	49
P-01465	50%	S14	NP-02	improved	56
P-01544	50%	S15	GI-04	improved	50
P-01570	50%	S14	SC-12	improved	46
P-01581	50%	S18	GI-04	improved	51
P-01716	50%	S14	GI-04	improved	56
P-01360	49%	S14	GI-04	improved	52
P-01365	48%	S14	SC-12	improved	49