Patient P-01860
Therapy response
Declining
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
89%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S20
- Day 82 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 82.
Primary contributors, last 14 days
- GI instability+28
- Inflammatory activity+25
- Nutritional resilience-19
- Toxicity+19
- Treatment adherence-15
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
65%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 92% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion61.6/100
worsening · +25.7 vs previous 14 d
Toxicity
Blood54.6/100
worsening · +22.6 vs previous 14 d
Sleep quality
Wearable17.8/100
worsening · -12.2 vs previous 14 d
Energy level
Daily log1.7/10
worsening · -1.9 vs previous 14 d
Stress level
Daily log7/10
worsening · +1.9 vs previous 14 d
Steps
Wearable5,617
worsening · -1,840 vs previous 14 d
Adherence
Companion76.4 %
stable · -1.5 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 39 from the failing basin, 61 from restoration.
Would help
Would not help
- Keep simple carbs lowGI +2.9 next day on high-intake days · n 17
- Keep histamine lowGI +2.8 next day on high-intake days · n 27
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Simple carbohydrates+2.9detractor · 95%
- Histamine load+2.8detractor · 95%
- Alcohol+1.3no signal · 43%
- Dietary fat load+0.9no signal · 32%
- Spicy / capsaicin+0.5no signal · 17%
- Insoluble fibre+0.4no signal · 16%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 62 and rising
- WearableSleep 5.4 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 28/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 62
- WearableHRV 37 ms, trending down
- Autonomic recovery ↓45
- WearableResting HR 73 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 55
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.3 · butyrate capacity 28/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 38 ms
- Sleep
- 5.8 h
- Steps
- 7,496
- Resting HR
- 67 bpm
Daily log: GI score 62, nutritional resilience 38, adherence 76.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01804 | 26% | S19 | AD-05 | improved | 61 |
| P-01679 | 23% | S12 | AD-05 | no change | 39 |
| P-01689 | 25% | S13 | BR-03 | no change | 50 |
| P-01329 | 22% | S08 | BR-03 | improved | 79 |
| P-01350 | 22% | S19 | BR-03 | no change | 34 |
| P-01371 | 38% | S06 | CR-01 | improved | 63 |
| P-01388 | 37% | S17 | CR-01 | improved | 59 |
| P-01696 | 36% | S20 | CR-01 | improved | 59 |
| P-01442 | 33% | S13 | CR-01 | improved | 61 |
| P-01835 | 31% | S17 | CR-01 | improved | 56 |
| P-01708 | 28% | S07 | CR-01 | improved | 59 |
| P-01877 | 27% | S01 | CR-01 | improved | 67 |