Patient P-01861

Synthetic patientNBL-101 · Day 98 · 55–64 · F · baseline S12Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Declining

Discontinuation risk

13%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S12
Day 12 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 14 HY-01 recommended — Hydration Protocol HY-01
Day 15 Patient accepted — Started HY-01 in the companion
Day 19 GI symptom burden −28% vs expected — Hydration Protocol HY-01
Day 25 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 12.

Primary contributors, last 14 days

Toxicity+9
Inflammatory activity-6
GI instability-5
Nutritional resilience-4
Treatment adherence+4

What helped?

Hydration Protocol HY-01Day 14
Result: symptom burden −28%

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

24.3/100

improving · -5.5 vs previous 14 d

Toxicity

Blood

16.3/100

improving · -4.1 vs previous 14 d

Sleep quality

Wearable

68.3/100

improving · +6.4 vs previous 14 d

Energy level

Daily log

6.2/10

stable · +0.0 vs previous 14 d

Stress level

Daily log

4.1/10

improving · -0.2 vs previous 14 d

Steps

Wearable

4,574

improving · +605 vs previous 14 d

Adherence

Companion

99.5 %

stable · -0.2 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 65 from the failing basin, 32 from restoration.

Would help

No untried action with strong evidence. Compose one from primitives.

Would not help

Keep histamine low
GI +3.8 next day on high-intake days · n 23
Keep fat low
GI +3.6 next day on high-intake days · n 24
Keep simple carbs low
GI +3.5 next day on high-intake days · n 18

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+3.8detractor · 95%
Dietary fat load
+3.6detractor · 95%
Simple carbohydrates
+3.5detractor · 95%
Alcohol
-1.8no signal · 47%
Spicy / capsaicin
-0.6no signal · 22%
Insoluble fibre
+0.5no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 39/100
Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Autonomic recovery ↓25
- WearableResting HR 74 bpm

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.7 · butyrate capacity 39/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 64 ms
Sleep: 8.0 h
Steps: 4,774
Resting HR: 75 bpm

Daily log: GI score 24, nutritional resilience 62, adherence 100.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01541	42%	S09	AD-05	no change	43
P-01377	41%	S11	AD-05	no change	42
P-01483	39%	S14	AD-05	no change	35
P-01679	35%	S12	AD-05	no change	39
P-01804	33%	S19	AD-05	improved	61
P-01773	28%	S05	AD-05	improved	27
P-01848	28%	S05	AD-05	no change	23
P-01689	40%	S13	BR-03	no change	50
P-01313	36%	S01	BR-03	improved	32
P-01350	35%	S19	BR-03	no change	34
P-01468	35%	S06	BR-03	no change	41
P-01450	34%	S09	BR-03	no change	36