Patient P-01865
Synthetic patientNBL-101 · Day 111 · 45–54 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 No meaningful change — Dietary Support Protocol NP-02
- Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 67 ME-01 recommended — Monitoring Escalation ME-01
- Day 68 Patient accepted — Started ME-01 in the companion
- Day 71 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 48.
Primary contributors, last 14 days
- Toxicity+12
- Nutritional resilience-11
- Inflammatory activity+10
- GI instability+6
- Treatment adherence+6
What helped?
- Dietary Support Protocol NP-02Day 31Result: no meaningful change
- Monitoring Escalation ME-01Day 67Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion61.5/100
worsening · +3.9 vs previous 14 d
Toxicity
Blood53/100
worsening · +3.9 vs previous 14 d
Sleep quality
Wearable0/100
worsening · -5.1 vs previous 14 d
Energy level
Daily log1.5/10
stable · -0.1 vs previous 14 d
Stress level
Daily log7.5/10
stable · +0.2 vs previous 14 d
Steps
Wearable7,595
worsening · -398 vs previous 14 d
Adherence
Companion49.5 %
improving · +4.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 29 from the failing basin, 64 from restoration.
Would help
Would not help
- NP-02 Dietary Support Protocolalready tried, no meaningful change
- Keep histamine lowGI +7.6 next day on high-intake days · n 24
- Keep fat lowGI +7.2 next day on high-intake days · n 20
- Keep fibre lowGI +5.9 next day on high-intake days · n 23
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+7.6detractor · 95%
- Dietary fat load+7.2detractor · 95%
- Insoluble fibre+5.9detractor · 95%
- Alcohol+3.5detractor · 69%
- Simple carbohydrates+1.1no signal · 18%
- Spicy / capsaicin-0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑95
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- BloodToxicity index 53
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 62 and rising
- WearableSleep 4.4 h, below personal baseline
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- WearableHRV 19 ms, trending down
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 30/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 74 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.2 · butyrate capacity 30/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 21 ms
- Sleep
- 5.1 h
- Steps
- 6,198
- Resting HR
- 73 bpm
Daily log: GI score 62, nutritional resilience 35, adherence 50.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01462 | 60% | S14 | NP-02 | improved | 47 |
| P-01872 | 59% | S14 | NP-02 | improved | 47 |
| P-01692 | 58% | S14 | NP-02 | improved | 49 |
| P-01393 | 56% | S14 | GI-04 | improved | 53 |
| P-01364 | 55% | S14 | GI-04 | improved | 49 |
| P-01482 | 52% | S14 | GI-04 | improved | 47 |
| P-01496 | 52% | S14 | SC-12 | improved | 46 |
| P-01573 | 52% | S14 | GI-04 | improved | 49 |
| P-01720 | 52% | S14 | NP-02 | improved | 47 |
| P-01760 | 52% | S14 | — | — | 42 |
| P-01879 | 52% | S14 | SC-12 | improved | 51 |
| P-01576 | 51% | S14 | NP-02 | no change | 49 |