Patient P-01891
Synthetic patientNBL-101 · Day 97 · 65–74 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Unstable
Tolerance
Stable
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
88%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 53 SC-12 recommended — Supportive Compound SC-12
- Day 54 Patient accepted — Started SC-12 in the companion
- Day 60 GI symptom burden −21% vs expected — Supportive Compound SC-12
- Day 66 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 49.
Primary contributors, last 14 days
- GI instability-11
- Inflammatory activity-8
- Nutritional resilience+6
- Treatment adherence-2
- Toxicity+2
What helped?
- Supportive Compound SC-12Day 53Result: symptom burden −21%
LIFE OS recommendation
GI Support Protocol GI-04
91%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion56.5/100
stable · +0.1 vs previous 14 d
Toxicity
Blood47.9/100
worsening · +3.5 vs previous 14 d
Sleep quality
Wearable37.3/100
improving · +4.7 vs previous 14 d
Energy level
Daily log2.4/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log5.8/10
worsening · +0.5 vs previous 14 d
Steps
Wearable2,957
worsening · -519 vs previous 14 d
Adherence
Companion48.5 %
worsening · -11.1 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 25 from the failing basin, 63 from restoration.
Would help
Would not help
- Keep histamine lowGI +6.7 next day on high-intake days · n 23
- Keep fat lowGI +6.6 next day on high-intake days · n 21
- Keep simple carbs lowGI +4.8 next day on high-intake days · n 15
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+6.7detractor · 95%
- Dietary fat load+6.6detractor · 95%
- Simple carbohydrates+4.8detractor · 95%
- Insoluble fibre+4.4detractor · 95%
- Spicy / capsaicin+4.1detractor · 88%
- Alcohol+0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 57 and rising
- WearableSleep 5.9 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 31/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 54
- Autonomic recovery ↑65
- WearableResting HR 73 bpm
- Wearable2,957 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 48
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.1 · butyrate capacity 31/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 49 ms
- Sleep
- 5.5 h
- Steps
- 3,202
- Resting HR
- 74 bpm
Daily log: GI score 57, nutritional resilience 44, adherence 49.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01494 | 65% | S14 | GI-04 | improved | 42 |
| P-01675 | 61% | S14 | NP-02 | improved | 38 |
| P-01732 | 51% | S14 | ME-01 | improved | 45 |
| P-01777 | 51% | S14 | SC-12 | improved | 43 |
| P-01413 | 50% | S14 | GI-04 | improved | 44 |
| P-01360 | 49% | S14 | GI-04 | improved | 52 |
| P-01488 | 48% | S12 | GI-04 | improved | 50 |
| P-01834 | 48% | S14 | NP-02 | improved | 44 |
| P-01436 | 47% | S14 | GI-04 | improved | 38 |
| P-01539 | 47% | S14 | GI-04 | improved | 43 |
| P-01781 | 47% | S14 | NP-02 | improved | 45 |
| P-01389 | 45% | S14 | SC-12 | improved | 46 |