Patient P-03049

Synthetic patientONX-7 · Day 139 · 55–64 · F · baseline S14Open companion preview

Therapy response

Improving

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

74%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 53 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 61 GI-04 recommended — GI Support Protocol GI-04
Day 62 Patient accepted — Started GI-04 in the companion
Day 70 GI symptom burden −21% vs expected — GI Support Protocol GI-04
Day 76 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 53.

Primary contributors, last 14 days

Inflammatory activity+6
Treatment adherence-6
Toxicity+6
Nutritional resilience-2

What helped?

GI Support Protocol GI-04Day 61
Result: symptom burden −21%

LIFE OS recommendation

Supportive Compound SC-12

70%

probability of meaningful tolerance improvement

284 similar trajectories
88% showed improvement
median effect visible after 6 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- WearableHRV 27 ms, trending down
Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 59 and rising
- WearableSleep 6.0 h, below personal baseline
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 39/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑45
- WearableResting HR 74 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 50

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Intermediate metabolizer
Expected exposure

Microbiome

Shannon diversity 2.9 · butyrate capacity 39/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 27 ms
Sleep: 5.3 h
Steps: 4,760
Resting HR: 75 bpm

Daily log: GI score 59, nutritional resilience 38, adherence 43.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03341	59%	S14	NP-02	improved	49
P-03323	51%	S14	GI-04	improved	48
P-03037	48%	S14	NP-02	improved	43
P-03081	47%	S10	GI-04	improved	53
P-03293	47%	S14	GI-04	no change	41
P-03390	47%	S14	ME-01	improved	41
P-03430	46%	S14	SC-12	improved	45
P-03123	44%	S14	GI-04	improved	50
P-03345	43%	S14	SC-12	improved	56
P-03003	42%	S08	SC-12	improved	53
P-03030	41%	S14	NP-02	improved	43
P-03090	41%	S02	GI-04	improved	48