Patient P-03123

Synthetic patientONX-7 · Day 123 · 35–44 · M · baseline S14Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Unstable

Discontinuation risk

61%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 39 NP-02 recommended — Dietary Support Protocol NP-02
Day 40 Patient accepted — Started NP-02 in the companion
Day 50 No meaningful change — Dietary Support Protocol NP-02
Day 55 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 63 GI-04 recommended — GI Support Protocol GI-04
Day 64 Patient accepted — Started GI-04 in the companion
Day 72 GI symptom burden −29% vs expected — GI Support Protocol GI-04
Day 78 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 55.

Primary contributors, last 14 days

GI instability-13
Treatment adherence+7
Inflammatory activity-4

What helped?

Dietary Support Protocol NP-02Day 39
Result: no meaningful change
GI Support Protocol GI-04Day 63
Result: symptom burden −29%

LIFE OS recommendation

Dosing / Timing Recommendation DT-01

68%

probability of meaningful tolerance improvement

284 similar trajectories
82% showed improvement
median effect visible after 5 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 39/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 50
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Autonomic recovery ↓25
- WearableResting HR 79 bpm
Drug metabolism and exposure ↑20
- BloodToxicity index 42

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.8 · butyrate capacity 39/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 42 ms
Sleep: 7.1 h
Steps: 4,601
Resting HR: 80 bpm

Daily log: GI score 45, nutritional resilience 40, adherence 50.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03146	51%	S14	GI-04	improved	53
P-03070	50%	S14	GI-04	improved	51
P-03090	47%	S02	GI-04	improved	48
P-03430	47%	S14	SC-12	improved	45
P-03049	44%	S14	GI-04	improved	49
P-03323	43%	S14	GI-04	improved	48
P-03300	42%	S14	GI-04	improved	46
P-03046	41%	S20	GI-04	no change	53
P-03110	41%	S15	GI-04	improved	52
P-03267	40%	S05	—	—	62
P-03289	40%	S03	SC-12	improved	54
P-03293	40%	S14	GI-04	no change	41