Patient P-03049
Therapy response
Improving
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
74%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 53 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 61 GI-04 recommended — GI Support Protocol GI-04
- Day 62 Patient accepted — Started GI-04 in the companion
- Day 70 GI symptom burden −21% vs expected — GI Support Protocol GI-04
- Day 76 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 53.
Primary contributors, last 14 days
- Inflammatory activity+6
- Treatment adherence-6
- Toxicity+6
- Nutritional resilience-2
What helped?
- GI Support Protocol GI-04Day 61Result: symptom burden −21%
LIFE OS recommendation
Supportive Compound SC-12
70%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 6 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.9/10
worsening · -1.0 vs previous 14 d
Stress level
Daily log6.8/10
worsening · +0.8 vs previous 14 d
Pessimism score
Daily log6.7/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable18.6/100
worsening · -7.7 vs previous 14 d
Libido
Daily log2.5/10
worsening · -0.7 vs previous 14 d
HRV
Wearable26.5 ms
worsening · -2.2 vs previous 14 d
Toxicity
Blood49.6/100
worsening · +6.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 28 from the failing basin, 63 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 66%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 66%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 66%
- More proteinGI -4.6 next day on high-intake days · n 16
- More alcoholGI -2.8 next day on high-intake days · n 20
Would not help
- AD-05 Adherence Supportonly 27% improved among 11 similar
- Keep histamine lowGI +5.1 next day on high-intake days · n 22
- Keep fat lowGI +5 next day on high-intake days · n 18
- Keep lactose lowGI +3.1 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.1detractor · 95%
- Dietary fat load+5detractor · 95%
- Protein-4.6supporter · 95%
- Lactose+3.1detractor · 69%
- Alcohol-2.8supporter · 60%
- Caffeine-0.8no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- WearableHRV 27 ms, trending down
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 59 and rising
- WearableSleep 6.0 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 39/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 74 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 50
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2.9 · butyrate capacity 39/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 27 ms
- Sleep
- 5.3 h
- Steps
- 4,760
- Resting HR
- 75 bpm
Daily log: GI score 59, nutritional resilience 38, adherence 43.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03341 | 59% | S14 | NP-02 | improved | 49 |
| P-03323 | 51% | S14 | GI-04 | improved | 48 |
| P-03037 | 48% | S14 | NP-02 | improved | 43 |
| P-03081 | 47% | S10 | GI-04 | improved | 53 |
| P-03293 | 47% | S14 | GI-04 | no change | 41 |
| P-03390 | 47% | S14 | ME-01 | improved | 41 |
| P-03430 | 46% | S14 | SC-12 | improved | 45 |
| P-03123 | 44% | S14 | GI-04 | improved | 50 |
| P-03345 | 43% | S14 | SC-12 | improved | 56 |
| P-03003 | 42% | S08 | SC-12 | improved | 53 |
| P-03030 | 41% | S14 | NP-02 | improved | 43 |
| P-03090 | 41% | S02 | GI-04 | improved | 48 |