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Patient P-03080

Synthetic patientONX-7 · Day 145 · 45–54 · F · baseline S09Steering view · 3DOpen companion preview
Therapy response
Favorable
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
62%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 ONX-7 started — Baseline state S09
  2. Day 69 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 69.

Primary contributors, last 14 days
  • Toxicity+15
  • Inflammatory activity+7
  • Treatment adherence+7

What helped?

No interventions yet.

    LIFE OS recommendation
    GI Support Protocol GI-04
    68%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 82% showed improvement
    • median effect visible after 8 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    Energy level
    Daily log
    2/10
    stable · -0.1 vs previous 14 d
    Stress level
    Daily log
    7/10
    stable · -0.2 vs previous 14 d
    Pessimism score
    Daily log
    5.8/10
    stable · +0.0 vs previous 14 d
    Sleep quality
    Wearable
    38.1/100
    stable · -0.0 vs previous 14 d
    Libido
    Daily log
    2.3/10
    worsening · -0.5 vs previous 14 d
    HRV
    Wearable
    38.3 ms
    stable · -0.5 vs previous 14 d
    Toxicity
    Blood
    60.8/100
    worsening · +14.5 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards failing · 38 from the failing basin, 67 from restoration.

    Would help
    • GI-04 GI Support Protocol
      73% improved among 33 similar · onset 8 d · confidence 68%
    • ME-01 Monitoring Escalation
      100% improved among 11 similar · onset 3 d · confidence 71%
    • SC-12 Supportive Compound
      89% improved among 9 similar · onset 6 d · confidence 71%
    • More protein
      GI -5.7 next day on high-intake days · n 20
    Would not help
    • Keep alcohol low
      GI +6.8 next day on high-intake days · n 24
    • Keep histamine low
      GI +5.8 next day on high-intake days · n 21
    • Keep lactose low
      GI +4.7 next day on high-intake days · n 14
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Alcohol
      +6.8detractor · 95%
    • Histamine load
      +5.8detractor · 95%
    • Protein
      -5.7supporter · 95%
    • Lactose
      +4.7detractor · 91%
    • Dietary fat load
      +0.4no signal · 15%
    • Caffeine
      -0.3no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Mucosal barrier integrity ↓80
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • MicrobiomeAkkermansia low → thinner mucus layer
      • Daily logGI symptom score 66 and rising
    • Inflammatory signalling ↑50
      • DNAIL6 -174 variant raises baseline inflammatory tone
      • BloodInflammatory load index 67
    • Autonomic recovery ↓25
      • WearableResting HR 83 bpm
    • Butyrate / short-chain fatty acid production ↓20
      • Daily logFibre intake low in recent food logs
    • Drug metabolism and exposure ↑20
      • BloodToxicity index 61
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • IL6 -174 G/C
      Higher inflammatory tone
    • CYP2D6 Intermediate metabolizer
      Expected exposure
    • MTHFR C677T
      Reduced folate turnover
    Microbiome
    Shannon diversity 2.9 · butyrate capacity 45/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisNormal
    • Bifidobacterium longumLow
    • EnterobacteriaceaeHigh
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    40 ms
    Sleep
    6.9 h
    Steps
    3,958
    Resting HR
    81 bpm
    Daily log: GI score 66, nutritional resilience 34, adherence 71.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
    • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Track each bowel movement today: time, stool form, urgency, overnight waking
    • A 15-minute walk after lunch
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • Electrolyte solution, one sachet after any loose stool
    • Fictional demo item: oral nutrition supplement with lunch

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0310519%S12AD-05no change60
    P-0320419%S16AD-05improved48
    P-0335119%S07AD-05no change51
    P-0348219%S05AD-05no change67
    P-0311118%S07AD-05no change48
    P-0318718%S12AD-05no change80
    P-0303417%S14AD-05no change30
    P-0327718%S14BR-03improved41
    P-0320817%S02BR-03improved57
    P-0309937%S17CR-01improved55
    P-0335737%S02CR-01improved50
    P-0316635%S20CR-01improved62