Patient P-03046
Therapy response
Declining
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Stable
Discontinuation risk
45%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S20
- Day 98 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient accepted — Started GI-04 in the companion
- Day 111 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 98.
Primary contributors, last 14 days
- GI instability-6
- Inflammatory activity-6
- Toxicity-6
- Nutritional resilience+4
- Treatment adherence-2
What helped?
- GI Support Protocol GI-04Day 102Result: no meaningful change
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
63%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓30
- Daily logGI symptom score 47 and rising
- WearableSleep 6.0 h, below personal baseline
- Inflammatory signalling ↓25
- BloodInflammatory load index 47
- Autonomic recovery ↑20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 3.1 · butyrate capacity 32/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 51 ms
- Sleep
- 5.8 h
- Steps
- 5,470
- Resting HR
- 71 bpm
Daily log: GI score 47, nutritional resilience 46, adherence 68.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03357 | 48% | S02 | CR-01 | improved | 50 |
| P-03465 | 47% | S17 | CR-01 | improved | 65 |
| P-03260 | 46% | S19 | — | — | 54 |
| P-03267 | 46% | S05 | — | — | 62 |
| P-03166 | 45% | S20 | CR-01 | improved | 62 |
| P-03352 | 43% | S19 | — | — | 59 |
| P-03382 | 43% | S01 | GI-04 | improved | 56 |
| P-03123 | 41% | S14 | GI-04 | improved | 50 |
| P-03201 | 41% | S15 | GI-04 | improved | 68 |
| P-03146 | 39% | S14 | GI-04 | improved | 53 |
| P-03225 | 39% | S19 | GI-04 | improved | 50 |
| P-03271 | 39% | S19 | — | — | 66 |