Patient P-03144
Therapy response
Improving
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Favorable
Nutritional resilience
Improving
Discontinuation risk
14%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S16
- Day 14 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 HY-01 recommended — Hydration Protocol HY-01
- Day 19 Patient accepted — Started HY-01 in the companion
- Day 23 GI symptom burden −30% vs expected — Hydration Protocol HY-01
- Day 29 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 14.
Primary contributors, last 14 days
- Nutritional resilience+8
- Treatment adherence-8
- Toxicity+5
- GI instability-4
What helped?
- Hydration Protocol HY-01Day 18Result: symptom burden −30%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑75
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↑20
- WearableShort sleep window
- Inflammatory signalling ↓15
- WearableHRV 35 ms, trending down
- Mucosal barrier integrity ↓10
- WearableSleep 5.6 h, below personal baseline
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.5 · butyrate capacity 38/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 37 ms
- Sleep
- 5.7 h
- Steps
- 9,298
- Resting HR
- 66 bpm
Daily log: GI score 20, nutritional resilience 68, adherence 92.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03179 | 55% | S05 | GI-04 | improved | 52 |
| P-03198 | 53% | S11 | — | — | 52 |
| P-03420 | 52% | S08 | — | — | 59 |
| P-03172 | 51% | S17 | DT-01 | no change | 48 |
| P-03372 | 51% | S19 | — | — | 53 |
| P-03489 | 49% | S04 | — | — | 54 |
| P-03097 | 48% | S16 | — | — | 60 |
| P-03233 | 47% | S19 | DT-01 | improved | 47 |
| P-03213 | 46% | S02 | DT-01 | improved | 59 |
| P-03215 | 46% | S16 | HY-01 | improved | 44 |
| P-03220 | 46% | S16 | — | — | 47 |
| P-03296 | 46% | S16 | — | — | 60 |