Patient P-03172
Therapy response
Declining
Tolerance
Favorable
GI state
Favorable
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
13%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S17
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 19 Patient accepted — Started DT-01 in the companion
- Day 24 No meaningful change — Dosing / Timing Recommendation DT-01
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- GI instability-4
- Toxicity+3
- Treatment adherence-2
What helped?
- Dosing / Timing Recommendation DT-01Day 18Result: no meaningful change
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 41/100
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↓35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 35 ms, trending down
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 41/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 36 ms
- Sleep
- 7.0 h
- Steps
- 9,734
- Resting HR
- 59 bpm
Daily log: GI score 17, nutritional resilience 66, adherence 90.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03144 | 51% | S16 | HY-01 | improved | 52 |
| P-03198 | 49% | S11 | — | — | 52 |
| P-03179 | 47% | S05 | GI-04 | improved | 52 |
| P-03233 | 46% | S19 | DT-01 | improved | 47 |
| P-03328 | 46% | S15 | GI-04 | improved | 59 |
| P-03420 | 45% | S08 | — | — | 59 |
| P-03220 | 44% | S16 | — | — | 47 |
| P-03484 | 44% | S07 | DT-01 | improved | 49 |
| P-03062 | 43% | S11 | — | — | 44 |
| P-03143 | 43% | S11 | DT-01 | improved | 49 |
| P-03255 | 43% | S01 | HY-01 | improved | 53 |
| P-03102 | 42% | S19 | — | — | 35 |