Patient P-03145
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
87%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 GI symptom burden −28% vs expected — Dietary Support Protocol NP-02
- Day 56 Tolerance state changed — Unstable → Improving
- Day 61 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 69 GI-04 recommended — GI Support Protocol GI-04
- Day 70 Patient accepted — Started GI-04 in the companion
- Day 78 GI symptom burden −30% vs expected — GI Support Protocol GI-04
- Day 84 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 61.
Primary contributors, last 14 days
- Nutritional resilience-18
- GI instability+17
- Inflammatory activity+13
- Toxicity+12
- Treatment adherence-8
What helped?
- Dietary Support Protocol NP-02Day 39Result: symptom burden −28%
- GI Support Protocol GI-04Day 69Result: symptom burden −30%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
70%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 75% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.5/10
worsening · -1.0 vs previous 14 d
Stress level
Daily log6.9/10
worsening · +1.1 vs previous 14 d
Pessimism score
Daily log5.7/10
worsening · +0.7 vs previous 14 d
Sleep quality
Wearable30.4/100
worsening · -8.0 vs previous 14 d
Libido
Daily log3.1/10
worsening · -0.8 vs previous 14 d
HRV
Wearable31.6 ms
worsening · -4.1 vs previous 14 d
Toxicity
Blood39.8/100
worsening · +11.6 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 33 from the failing basin, 56 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 77%
- DT-01 Dosing / Timing Recommendation75% improved among 12 similar · onset 5 d · confidence 77%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 77%
- More proteinGI -5.7 next day on high-intake days · n 25
Would not help
- AD-05 Adherence Supportonly 30% improved among 10 similar
- Keep fat lowGI +5.4 next day on high-intake days · n 19
- Keep lactose lowGI +5 next day on high-intake days · n 15
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.7supporter · 95%
- Dietary fat load+5.4detractor · 95%
- Lactose+5detractor · 95%
- Histamine load-1.4no signal · 28%
- Alcohol+0.3no signal · 15%
- Caffeine-0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 53
- WearableHRV 32 ms, trending down
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 42/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 57 and rising
- WearableSleep 6.1 h, below personal baseline
- Autonomic recovery ↓40
- Wearable300 steps/day
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.5 · butyrate capacity 42/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 38 ms
- Sleep
- 5.7 h
- Steps
- 1,580
- Resting HR
- 67 bpm
Daily log: GI score 57, nutritional resilience 36, adherence 47.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.