Patient P-03145

Synthetic patientONX-7 · Day 139 · 55–64 · M · baseline S14Open companion preview

Therapy response

Improving

Tolerance

Deteriorating

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Unstable

Discontinuation risk

87%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 39 NP-02 recommended — Dietary Support Protocol NP-02
Day 40 Patient accepted — Started NP-02 in the companion
Day 50 GI symptom burden −28% vs expected — Dietary Support Protocol NP-02
Day 56 Tolerance state changed — Unstable → Improving
Day 61 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 69 GI-04 recommended — GI Support Protocol GI-04
Day 70 Patient accepted — Started GI-04 in the companion
Day 78 GI symptom burden −30% vs expected — GI Support Protocol GI-04
Day 84 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 61.

Primary contributors, last 14 days

Nutritional resilience-18
GI instability+17
Inflammatory activity+13
Toxicity+12
Treatment adherence-8

What helped?

Dietary Support Protocol NP-02Day 39
Result: symptom burden −28%
GI Support Protocol GI-04Day 69
Result: symptom burden −30%

LIFE OS recommendation

Dosing / Timing Recommendation DT-01

70%

probability of meaningful tolerance improvement

284 similar trajectories
75% showed improvement
median effect visible after 5 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 53
- WearableHRV 32 ms, trending down
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 42/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 57 and rising
- WearableSleep 6.1 h, below personal baseline
Autonomic recovery ↓40
- Wearable300 steps/day
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.5 · butyrate capacity 42/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 38 ms
Sleep: 5.7 h
Steps: 1,580
Resting HR: 67 bpm

Daily log: GI score 57, nutritional resilience 36, adherence 47.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03070	47%	S14	GI-04	improved	51
P-03090	47%	S02	GI-04	improved	48
P-03300	44%	S14	GI-04	improved	46
P-03146	42%	S14	GI-04	improved	53
P-03049	41%	S14	GI-04	improved	49
P-03110	41%	S15	GI-04	improved	52
P-03159	40%	S14	GI-04	improved	37
P-03323	40%	S14	GI-04	improved	48
P-03123	39%	S14	GI-04	improved	50
P-03226	38%	S05	GI-04	improved	43
P-03225	37%	S19	GI-04	improved	50
P-03430	37%	S14	SC-12	improved	45