Patient P-03183
Therapy response
Declining
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
64%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S03
- Day 96 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 96.
Primary contributors, last 14 days
- Toxicity-8
- Inflammatory activity+5
- Treatment adherence-5
- GI instability+4
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 73 and rising
- WearableSleep 5.3 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 37/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 77 bpm
- WearableShort sleep window
- Inflammatory signalling ↑40
- BloodInflammatory load index 62
- WearableHRV 32 ms, trending down
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.6 · butyrate capacity 37/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 30 ms
- Sleep
- 5.1 h
- Steps
- 5,583
- Resting HR
- 79 bpm
Daily log: GI score 73, nutritional resilience 37, adherence 64.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03280 | 49% | S13 | — | — | 57 |
| P-03065 | 46% | S16 | — | — | 59 |
| P-03384 | 44% | S01 | — | — | 55 |
| P-03099 | 43% | S17 | CR-01 | improved | 55 |
| P-03151 | 41% | S18 | — | — | 51 |
| P-03004 | 40% | S03 | — | — | 56 |
| P-03080 | 40% | S09 | — | — | 62 |
| P-03191 | 40% | S19 | GI-04 | improved | 51 |
| P-03225 | 40% | S19 | GI-04 | improved | 50 |
| P-03444 | 40% | S17 | — | — | 62 |
| P-03260 | 39% | S19 | — | — | 54 |
| P-03166 | 38% | S20 | CR-01 | improved | 62 |