Patient P-03183
Therapy response
Declining
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
64%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S03
- Day 96 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 96.
Primary contributors, last 14 days
- Toxicity-8
- Inflammatory activity+5
- Treatment adherence-5
- GI instability+4
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.8/10
worsening · -0.6 vs previous 14 d
Stress level
Daily log7.8/10
worsening · +0.7 vs previous 14 d
Pessimism score
Daily log5.8/10
worsening · +0.6 vs previous 14 d
Sleep quality
Wearable14.1/100
worsening · -3.9 vs previous 14 d
Libido
Daily log2.1/10
worsening · -0.6 vs previous 14 d
HRV
Wearable32.2 ms
worsening · -3.1 vs previous 14 d
Toxicity
Blood36.8/100
worsening · +6.5 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 32 from the failing basin, 72 from restoration.
Would help
- GI-04 GI Support Protocol73% improved among 33 similar · onset 8 d · confidence 59%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 61%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 61%
- More proteinGI -4.1 next day on high-intake days · n 15
Would not help
- AD-05 Adherence Supportonly 17% improved among 12 similar
- Keep fat lowGI +3.3 next day on high-intake days · n 21
- Keep histamine lowGI +2.5 next day on high-intake days · n 24
- Keep caffeine lowGI +2.3 next day on high-intake days · n 16
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.1supporter · 95%
- Dietary fat load+3.3detractor · 93%
- Histamine load+2.5detractor · 79%
- Caffeine+2.3detractor · 63%
- Alcohol-0.7no signal · 19%
- Lactose+0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 73 and rising
- WearableSleep 5.3 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 37/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 77 bpm
- WearableShort sleep window
- Inflammatory signalling ↑40
- BloodInflammatory load index 62
- WearableHRV 32 ms, trending down
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.6 · butyrate capacity 37/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 30 ms
- Sleep
- 5.1 h
- Steps
- 5,583
- Resting HR
- 79 bpm
Daily log: GI score 73, nutritional resilience 37, adherence 64.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03204 | 21% | S16 | AD-05 | improved | 48 |
| P-03105 | 20% | S12 | AD-05 | no change | 60 |
| P-03111 | 20% | S07 | AD-05 | no change | 48 |
| P-03351 | 20% | S07 | AD-05 | no change | 51 |
| P-03482 | 20% | S05 | AD-05 | no change | 67 |
| P-03034 | 19% | S14 | AD-05 | no change | 30 |
| P-03369 | 19% | S18 | AD-05 | no change | 37 |
| P-03424 | 19% | S12 | AD-05 | improved | 41 |
| P-03122 | 18% | S13 | AD-05 | no change | 40 |
| P-03129 | 18% | S18 | AD-05 | no change | 32 |
| P-03158 | 18% | S17 | AD-05 | no change | 37 |
| P-03187 | 18% | S12 | AD-05 | no change | 80 |