Patient P-03280
Therapy response
Declining
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
70%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S13
- Day 75 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 75.
Primary contributors, last 14 days
- Toxicity+12
- Inflammatory activity+10
- GI instability+8
- Nutritional resilience-4
- Treatment adherence-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
67%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 38/100
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 67 and rising
- Autonomic recovery ↓45
- WearableResting HR 78 bpm
- Wearable1,825 steps/day
- Inflammatory signalling ↑40
- BloodInflammatory load index 62
- WearableHRV 30 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 50
DNA
Fictional pharmacogenomic panel
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 35 ms
- Sleep
- 6.8 h
- Steps
- 779
- Resting HR
- 79 bpm
Daily log: GI score 67, nutritional resilience 37, adherence 65.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03183 | 49% | S03 | — | — | 54 |
| P-03099 | 47% | S17 | CR-01 | improved | 55 |
| P-03444 | 47% | S17 | — | — | 62 |
| P-03352 | 45% | S19 | — | — | 59 |
| P-03225 | 44% | S19 | GI-04 | improved | 50 |
| P-03004 | 43% | S03 | — | — | 56 |
| P-03080 | 43% | S09 | — | — | 62 |
| P-03191 | 43% | S19 | GI-04 | improved | 51 |
| P-03166 | 42% | S20 | CR-01 | improved | 62 |
| P-03384 | 41% | S01 | — | — | 55 |
| P-03451 | 41% | S08 | — | — | 62 |
| P-03031 | 40% | S16 | CR-01 | improved | 49 |