Patient P-03191
Therapy response
Declining
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
59%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S19
- Day 97 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient accepted — Started GI-04 in the companion
- Day 111 GI symptom burden −14% vs expected — GI Support Protocol GI-04
- Day 117 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 97.
Primary contributors, last 14 days
- Nutritional resilience-13
- GI instability+6
- Toxicity+5
- Treatment adherence+4
What helped?
- GI Support Protocol GI-04Day 102Result: symptom burden −14%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
63%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.7/10
improving · +0.3 vs previous 14 d
Stress level
Daily log6.6/10
stable · -0.1 vs previous 14 d
Pessimism score
Daily log6.1/10
stable · +0.1 vs previous 14 d
Sleep quality
Wearable18.6/100
improving · +2.4 vs previous 14 d
Libido
Daily log2.6/10
improving · +0.1 vs previous 14 d
HRV
Wearable27.4 ms
improving · +1.7 vs previous 14 d
Toxicity
Blood50.5/100
improving · -4.5 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 35 from the failing basin, 55 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 62%
- DT-01 Dosing / Timing Recommendation82% improved among 11 similar · onset 5 d · confidence 62%
- SC-12 Supportive Compound100% improved among 8 similar · onset 6 d · confidence 62%
- More proteinGI -3 next day on high-intake days · n 11
Would not help
- AD-05 Adherence Supportonly 20% improved among 10 similar
- Keep lactose lowGI +3.3 next day on high-intake days · n 23
- Keep histamine lowGI +2 next day on high-intake days · n 20
- Keep alcohol lowGI +1.8 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Lactose+3.3detractor · 95%
- Protein-3supporter · 95%
- Histamine load+2detractor · 68%
- Alcohol+1.8detractor · 68%
- Dietary fat load+0.5no signal · 15%
- Caffeine+0.5no signal · 18%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 57 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 83 bpm
- WearableShort sleep window
- Inflammatory signalling ↓40
- BloodInflammatory load index 49
- WearableHRV 27 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 51
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.5 · butyrate capacity 47/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 32 ms
- Sleep
- 5.8 h
- Steps
- 7,817
- Resting HR
- 83 bpm
Daily log: GI score 57, nutritional resilience 35, adherence 73.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03099 | 44% | S17 | CR-01 | improved | 55 |
| P-03225 | 42% | S19 | GI-04 | improved | 50 |
| P-03166 | 41% | S20 | CR-01 | improved | 62 |
| P-03357 | 38% | S02 | CR-01 | improved | 50 |
| P-03031 | 37% | S16 | CR-01 | improved | 49 |
| P-03382 | 37% | S01 | GI-04 | improved | 56 |
| P-03081 | 36% | S10 | GI-04 | improved | 53 |
| P-03226 | 35% | S05 | GI-04 | improved | 43 |
| P-03465 | 35% | S17 | CR-01 | improved | 65 |
| P-03049 | 34% | S14 | GI-04 | improved | 49 |
| P-03201 | 34% | S15 | GI-04 | improved | 68 |
| P-03323 | 34% | S14 | GI-04 | improved | 48 |