Patient P-03279
Therapy response
Declining
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
54%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 61 GI-04 recommended — GI Support Protocol GI-04
- Day 62 Patient accepted — Started GI-04 in the companion
- Day 70 GI symptom burden −34% vs expected — GI Support Protocol GI-04
- Day 76 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 58.
Primary contributors, last 14 days
- Treatment adherence-25
- Toxicity+9
- Inflammatory activity+2
What helped?
- GI Support Protocol GI-04Day 61Result: symptom burden −34%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 90% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.6/10
improving · +0.3 vs previous 14 d
Stress level
Daily log5.6/10
improving · -0.4 vs previous 14 d
Pessimism score
Daily log5.1/10
stable · +0.2 vs previous 14 d
Sleep quality
Wearable28/100
stable · +1.5 vs previous 14 d
Libido
Daily log2.9/10
stable · -0.1 vs previous 14 d
HRV
Wearable61.6 ms
stable · +1.9 vs previous 14 d
Toxicity
Blood36.8/100
worsening · +3.8 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 49 from the failing basin, 38 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 56%
- DT-01 Dosing / Timing Recommendation90% improved among 10 similar · onset 5 d · confidence 56%
- CR-01 Clinician Review100% improved among 5 similar · onset 5 d · confidence 56%
- More proteinGI -7.3 next day on high-intake days · n 25
Would not help
- Keep lactose lowGI +6.1 next day on high-intake days · n 20
- Keep histamine lowGI +5.9 next day on high-intake days · n 18
- Keep fat lowGI +4.2 next day on high-intake days · n 17
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-7.3supporter · 95%
- Lactose+6.1detractor · 95%
- Histamine load+5.9detractor · 95%
- Dietary fat load+4.2detractor · 85%
- Caffeine-1.1no signal · 17%
- Alcohol+1.1no signal · 19%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 42
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 5.7 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.9 · butyrate capacity 46/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 60 ms
- Sleep
- 6.5 h
- Steps
- 4,916
- Resting HR
- 77 bpm
Daily log: GI score 42, nutritional resilience 53, adherence 62.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.