Patient P-03279

Synthetic patientONX-7 · Day 94 · 25–34 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Stable

Discontinuation risk

54%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 61 GI-04 recommended — GI Support Protocol GI-04
Day 62 Patient accepted — Started GI-04 in the companion
Day 70 GI symptom burden −34% vs expected — GI Support Protocol GI-04
Day 76 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 58.

Primary contributors, last 14 days

Treatment adherence-25
Toxicity+9
Inflammatory activity+2

What helped?

GI Support Protocol GI-04Day 61
Result: symptom burden −34%

LIFE OS recommendation

Dosing / Timing Recommendation DT-01

62%

probability of meaningful tolerance improvement

284 similar trajectories
90% showed improvement
median effect visible after 5 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Energy level

Daily log

3.6/10

improving · +0.3 vs previous 14 d

Stress level

Daily log

5.6/10

improving · -0.4 vs previous 14 d

Pessimism score

Daily log

5.1/10

stable · +0.2 vs previous 14 d

Sleep quality

Wearable

28/100

stable · +1.5 vs previous 14 d

Libido

Daily log

2.9/10

stable · -0.1 vs previous 14 d

HRV

Wearable

61.6 ms

stable · +1.9 vs previous 14 d

Toxicity

Blood

36.8/100

worsening · +3.8 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 49 from the failing basin, 38 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 11 similar · onset 3 d · confidence 56%
DT-01 Dosing / Timing Recommendation
90% improved among 10 similar · onset 5 d · confidence 56%
CR-01 Clinician Review
100% improved among 5 similar · onset 5 d · confidence 56%
More protein
GI -7.3 next day on high-intake days · n 25

Would not help

Keep lactose low
GI +6.1 next day on high-intake days · n 20
Keep histamine low
GI +5.9 next day on high-intake days · n 18
Keep fat low
GI +4.2 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-7.3supporter · 95%
Lactose
+6.1detractor · 95%
Histamine load
+5.9detractor · 95%
Dietary fat load
+4.2detractor · 85%
Caffeine
-1.1no signal · 17%
Alcohol
+1.1no signal · 19%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 42
Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 5.7 h, below personal baseline
Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 1.9 · butyrate capacity 46/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 60 ms
Sleep: 6.5 h
Steps: 4,916
Resting HR: 77 bpm

Daily log: GI score 42, nutritional resilience 53, adherence 62.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03289	46%	S03	SC-12	improved	54
P-03123	39%	S14	GI-04	improved	50
P-03146	38%	S14	GI-04	improved	53
P-03103	37%	S14	GI-04	improved	63
P-03110	37%	S15	GI-04	improved	52
P-03465	37%	S17	CR-01	improved	65
P-03070	36%	S14	GI-04	improved	51
P-03357	36%	S02	CR-01	improved	50
P-03201	35%	S15	GI-04	improved	68
P-03300	35%	S14	GI-04	improved	46
P-03365	33%	S14	NP-02	improved	46
P-03382	33%	S01	GI-04	improved	56