Patient P-03365
Therapy response
Declining
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
74%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 GI symptom burden −22% vs expected — Dietary Support Protocol NP-02
- Day 56 Tolerance state changed — Unstable → Improving
- Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 81 ME-01 recommended — Monitoring Escalation ME-01
- Day 82 Patient accepted — Started ME-01 in the companion
- Day 85 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 58.
Primary contributors, last 14 days
- Treatment adherence-26
- GI instability-15
- Inflammatory activity-10
- Toxicity-7
- Nutritional resilience+6
What helped?
- Dietary Support Protocol NP-02Day 39Result: symptom burden −22%
- Monitoring Escalation ME-01Day 81Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
81%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log4.4/10
stable · +0.0 vs previous 14 d
Stress level
Daily log7.1/10
stable · -0.2 vs previous 14 d
Pessimism score
Daily log5.7/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable53.4/100
improving · +3.6 vs previous 14 d
Libido
Daily log3.3/10
stable · +0.1 vs previous 14 d
HRV
Wearable22.5 ms
improving · +2.0 vs previous 14 d
Toxicity
Blood43.3/100
worsening · +2.8 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 42 from the failing basin, 45 from restoration.
Would help
- GI-04 GI Support Protocol73% improved among 33 similar · onset 8 d · confidence 84%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 69%
- HY-01 Hydration Protocol63% improved among 8 similar · onset 4 d · confidence 69%
- More proteinGI -6.9 next day on high-intake days · n 24
Would not help
- AD-05 Adherence Supportonly 36% improved among 11 similar
- Keep alcohol lowGI +5.8 next day on high-intake days · n 16
- Keep fat lowGI +5.6 next day on high-intake days · n 24
- Keep histamine lowGI +4.8 next day on high-intake days · n 26
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-6.9supporter · 95%
- Alcohol+5.8detractor · 95%
- Dietary fat load+5.6detractor · 95%
- Histamine load+4.8detractor · 95%
- Lactose+4.7detractor · 95%
- Caffeine-1no signal · 17%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 43
- WearableHRV 23 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 43
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.8 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 25 ms
- Sleep
- 6.9 h
- Steps
- 5,318
- Resting HR
- 69 bpm
Daily log: GI score 42, nutritional resilience 49, adherence 60.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03382 | 31% | S01 | GI-04 | improved | 56 |
| P-03384 | 28% | S01 | — | — | 55 |
| P-03074 | 26% | S01 | — | — | 60 |
| P-03381 | 25% | S01 | — | — | 55 |
| P-03389 | 24% | S01 | — | — | 50 |
| P-03443 | 24% | S01 | — | — | 52 |
| P-03092 | 23% | S01 | — | — | 61 |
| P-03255 | 23% | S01 | HY-01 | improved | 53 |
| P-03128 | 21% | S01 | — | — | 32 |
| P-03090 | 29% | S02 | GI-04 | improved | 48 |
| P-03357 | 27% | S02 | CR-01 | improved | 50 |
| P-03301 | 25% | S02 | — | — | 62 |