Patient P-03365

Synthetic patientONX-7 · Day 93 · 65–74 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Improving

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

74%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 39 NP-02 recommended — Dietary Support Protocol NP-02
Day 40 Patient accepted — Started NP-02 in the companion
Day 50 GI symptom burden −22% vs expected — Dietary Support Protocol NP-02
Day 56 Tolerance state changed — Unstable → Improving
Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 81 ME-01 recommended — Monitoring Escalation ME-01
Day 82 Patient accepted — Started ME-01 in the companion
Day 85 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 58.

Primary contributors, last 14 days

Treatment adherence-26
GI instability-15
Inflammatory activity-10
Toxicity-7
Nutritional resilience+6

What helped?

Dietary Support Protocol NP-02Day 39
Result: symptom burden −22%
Monitoring Escalation ME-01Day 81
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

81%

probability of meaningful tolerance improvement

284 similar trajectories
82% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Energy level

Daily log

4.4/10

stable · +0.0 vs previous 14 d

Stress level

Daily log

7.1/10

stable · -0.2 vs previous 14 d

Pessimism score

Daily log

5.7/10

worsening · +0.5 vs previous 14 d

Sleep quality

Wearable

53.4/100

improving · +3.6 vs previous 14 d

Libido

Daily log

3.3/10

stable · +0.1 vs previous 14 d

HRV

Wearable

22.5 ms

improving · +2.0 vs previous 14 d

Toxicity

Blood

43.3/100

worsening · +2.8 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 42 from the failing basin, 45 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 33 similar · onset 8 d · confidence 84%
SC-12 Supportive Compound
89% improved among 9 similar · onset 6 d · confidence 69%
HY-01 Hydration Protocol
63% improved among 8 similar · onset 4 d · confidence 69%
More protein
GI -6.9 next day on high-intake days · n 24

Would not help

AD-05 Adherence Support
only 36% improved among 11 similar
Keep alcohol low
GI +5.8 next day on high-intake days · n 16
Keep fat low
GI +5.6 next day on high-intake days · n 24
Keep histamine low
GI +4.8 next day on high-intake days · n 26

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-6.9supporter · 95%
Alcohol
+5.8detractor · 95%
Dietary fat load
+5.6detractor · 95%
Histamine load
+4.8detractor · 95%
Lactose
+4.7detractor · 95%
Caffeine
-1no signal · 17%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 43
- WearableHRV 23 ms, trending down
Drug metabolism and exposure ↑20
- BloodToxicity index 43

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 1.8 · butyrate capacity 38/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 25 ms
Sleep: 6.9 h
Steps: 5,318
Resting HR: 69 bpm

Daily log: GI score 42, nutritional resilience 49, adherence 60.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03103	47%	S14	GI-04	improved	63
P-03289	36%	S03	SC-12	improved	54
P-03031	35%	S16	CR-01	improved	49
P-03159	34%	S14	GI-04	improved	37
P-03021	33%	S15	—	—	57
P-03226	33%	S05	GI-04	improved	43
P-03279	33%	S14	GI-04	improved	57
P-03463	33%	S11	GI-04	no change	55
P-03382	31%	S01	GI-04	improved	56
P-03123	30%	S14	GI-04	improved	50
P-03280	30%	S13	—	—	57
P-03379	30%	S12	GI-04	improved	51